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3 results on '"D. Baretta"'

1. Experimental human exposure to carbon monoxide

Author

Jack E. Peterson, Richard D. Stewart, Romeo T. Bachand, Michael J. Hosko, Anthony A. Herrmann, and Edward D. Baretta

Subjects
Adult, Male, Time Factors, Poison control, Environment, Toxicology, chemistry.chemical_compound, Hemoglobins, Air Pollution, medicine, Methods, Reaction Time, Environmental Chemistry, Humans, Compounds of carbon, General Environmental Science, Visual Cortex, chemistry.chemical_classification, Carbon Monoxide, business.industry, Public Health, Environmental and Occupational Health, Headache, Electroencephalography, Environmental exposure, Environmental Exposure, Adaptation, Physiological, Human Experimentation, chemistry, Carbon oxide, Human exposure, Motor Skills, Anesthesia, Carboxyhemoglobin, Time Perception, Headaches, medicine.symptom, business, Carbon monoxide
Abstract

Human volunteers were exposed to carbon monoxide at concentrations of < 1, 25, 50, 100, 200, 500, and 1,000 ppm for periods of one-half to 24 hours. No untoward effects were observed in sedentary males exposed to 100 ppm for eight hours. Exposures producing carboxyhemoglobin saturations greater than 15% to 20% resulted in delayed headaches, changes in the visual evoked response, and impairment of manual coordination.

Published
1970

3. Experimental human exposure to methylene chloride

Author

Edward D. Baretta, Jack E. Peterson, Richard D. Stewart, Terrance N. Fisher, Michael J. Hosko, and Hugh C. Dodd

Subjects
Adult, Central Nervous System, Male, Chromatography, Gas, Time Factors, Spectrophotometry, Infrared, Metabolite, Inorganic chemistry, Chloride, chemistry.chemical_compound, Hemoglobins, Chlorides, medicine, Environmental Chemistry, Humans, Methylene, General Environmental Science, Carbon Monoxide, Inhalation, Hydrocarbons, Halogenated, Respiration, Public Health, Environmental and Occupational Health, Environmental Exposure, Solvent, chemistry, Carboxyhemoglobin, Solvents, Maximum Allowable Concentration, Saturation (chemistry), Nuclear chemistry, Carbon monoxide, medicine.drug
Abstract

Inhalation of methylene chloride vapor In concentrations of 500 to 1,000 ppm for one to two hours was followed promptly by a sustained elevation of carboxyhemoglobin level in all 11 subjects studied. The evidence suggests that carbon monoxide may fee a metabolite of methylene chloride and that exposure to concentrations of methylene chloride that do not exceed the Industrial Threshold Limit Value for that solvent may result in a carboxyhemoglobin saturation level in excess of that allowable from carbon monoxide itself. In addition, methylene chloride produced signs and symptoms of central nervous system depression in subjects exposed to vapor concentrations of 1,000 ppm.

Published
1972

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