1. Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants
- Author
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Rimona Keidar, D Batash, Shaul Baram, Bernard Barzilay, Eli Heyman, Ilan Youngster, Matithiahu Berkovitch, and Michael Goldman
- Subjects
Male ,Administration, Oral ,Gestational Age ,Ibuprofen ,Infant, Premature, Diseases ,Drug Administration Schedule ,Pharmacokinetics ,Oral administration ,Ductus arteriosus ,medicine ,Birth Weight ,Humans ,Cyclooxygenase Inhibitors ,Prospective Studies ,Adverse effect ,Ductus Arteriosus, Patent ,business.industry ,Ductus arteriosus closure ,organic chemicals ,Infant, Newborn ,Area under the curve ,Obstetrics and Gynecology ,Gestational age ,General Medicine ,medicine.anatomical_structure ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Female ,business ,Infant, Premature ,medicine.drug - Abstract
Background Oral ibuprofen has been shown to be associated with excellent patent ductus arteriosus (PDA) closure rates and a favourable safety profile, but limited data exist regarding its pharmacokinetics in preterm infants. Objective To evaluate pharmacokinetic parameters of oral ibuprofen in preterm infants. Methods Plasma ibuprofen levels were determined at various time points, and pharmacokinetic profiles were calculated after a single dose of 10 mg/kg of oral ibuprofen. The rate of ductal closure, adverse effects and patients9 clinical course were recorded. Results The authors studied 13 preterm infants (mean gestational age±SD 27.8±2.4 weeks, mean birth weight 1052±443 g). PDA closure was obtained in all patients after a single dose. Ibuprofen levels were detectable 1 h after administration, peaked after 8 h and remained in a relative plateau until 24 h postadministration. Area under the curve (AUC)0→24 was higher than levels reported with intravenous treatment. No adverse effects were observed. Conclusion Oral administration of ibuprofen in very preterm infants is associated with excellent absorption and a high AUC0→24, and may be an alternative to intravenous administration.
- Published
- 2011