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8 results on '"Biran V"'

1. O26 Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young Infants

Author

Jacqz-Aigrain, E, primary, Leroux, S, additional, Thomson, AH, additional, Allegaert, K, additional, Capparelli, EV, additional, Biran, V, additional, Simon, N, additional, Meibohm, B, additional, Y-L, Lo, additional, Marqués, R, additional, Peris, J-E, additional, Lutsar, I, additional, Saito, J, additional, Nayamura, H, additional, van den Anker, JN, additional, Sharland, M, additional, and Zhao, W, additional

Published
2019
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4. O-101 Number Of Procedures And Analgesic Therapy In Neonates Admitted To Nicus: Epippain 2 Study

Author

Carbajal, R, primary, Courtois, E, additional, Droutman, S, additional, Magny, JF, additional, Merchaoui, Z, additional, Durrmeyer, X, additional, Roussel, C, additional, Biran, V, additional, Renolleau, S, additional, Desfrere, L, additional, Castela, F, additional, Boimond, N, additional, Mellah, D, additional, Bolot, P, additional, Coursol, A, additional, El Ayoubi, M, additional, Eleni, S, additional, Brault, D, additional, E, Epippain, additional, Cimerman, P, additional, and Anand, KJS, additional

Published
2014
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5. O-147 Frequency Of Heelsticks And Analgesic Management In Neonates Admitted To Neonatal Intensive Care Units (nicus): Epippain 2 Study (epidemiology Of Procedural Pain In Neonates)

Author

Courtois, E, primary, Droutman, S, additional, Magny, JF, additional, Merchaoui, Z, additional, Durrmeyer, X, additional, Roussel, C, additional, Biran, V, additional, Eleni, S, additional, Vottier, G, additional, Renolleau, S, additional, Desfrere, L, additional, Castela, F, additional, Boimond, N, additional, Mellah, D, additional, Bolot, P, additional, Coursol, A, additional, Brault, D, additional, Cimerman, P, additional, Anand, KJS, additional, and Carbajal, R, additional

Published
2014
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8. Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring.

Author

Zhao W, Lopez E, Biran V, Durrmeyer X, Fakhoury M, and Jacqz-Aigrain E

Subjects
Anti-Bacterial Agents pharmacokinetics, Birth Weight, Dose-Response Relationship, Drug, Drug Monitoring methods, Female, Humans, Infant, Newborn, Infusions, Intravenous methods, Male, Models, Theoretical, Vancomycin pharmacokinetics, Anti-Bacterial Agents administration & dosage, Vancomycin administration & dosage
Abstract

Objective: Because pharmacokinetic data are limited, continuous infusions of vancomycin in neonates are administered using different dosing regimens. The aim of this work was to evaluate the results of vancomycin therapeutic drug monitoring (TDM) under three different dosing regimens and to optimise vancomycin therapy., Methods: Vancomycin TDM concentrations were noted and compared prospectively in three hospitals. Population pharmacokinetic analysis was performed to optimise dosing using NONMEM software. Patient-tailored optimised dosing regimens were evaluated in a prospective study., Results: Two hundred and seven serum vancomycin concentrations from 116 neonates were analysed. Only 48 neonates (41%) had serum vancomycin concentrations within the therapeutic range of 15-25 mg/l using a current dosing regimen. Concentrations ranged from 5.1 to 61.5 mg/l. Loading doses were required to decrease the risk of sub-therapeutic levels during early treatment. An optimised dosing regimen, taking into account birth weight, current weight, postnatal age and serum creatinine, was developed based on a one-compartment pharmacokinetic model. A prospective validation study in 58 neonates demonstrated a higher percentage of neonates (70.7%, n=41) reaching the therapeutic range and early dosage adaptation (6-12 h post-dose) using an optimised dosing regimen., Conclusions: A patient-tailored optimised dosing regimen should be used routinely to individualise vancomycin continuous infusion therapy in neonates.

Published
2013
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