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Your search keyword '"Taylor, R W"' showing total 3 results
Start Over Author "Taylor, R W" Publication Year Range Last 50 years Journal archives of disease in childhood
3 results on '"Taylor, R W"'

3. Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).

Author

McFarland R, Hudson G, Taylor RW, Green SH, Hodges S, McKiernan PJ, Chinnery PF, Ramesh V, McFarland, R, Hudson, G, Taylor, R W, Green, S H, Hodges, S, McKiernan, P J, Chinnery, P F, and Ramesh, V

Abstract

We report the case of a 2-year-old boy with seizures who developed hepatic failure shortly after commencing sodium valproate. Unexpectedly, liver function returned to normal on stopping the drug. Sequencing of the mitochondrial polymerase gamma gene (POLG1) revealed four heterozygous substitutions, two of which have been identified in cases of Alpers-Huttenlocher disease. [ABSTRACT FROM AUTHOR]

Published
2008
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