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• Background and Methods.— Because acne is androgen dependent, antiandrogen therapy might improve the condition. Inocoterone acetate (RU 882) is a nonsteroidal antiandrogen that binds to the androgen receptor and has antiandrogenic activity in animal models. To test its topical effect on acne, 126 male subjects with facial acne completed a 16-week, multicenter, double-blind study in which the twicedaily application of a 10% solution of inocoterone was compared with vehicle solution. Baseline and monthly examinations included acne lesion counts and general and endocrine laboratory tests. Results.— Inflammatory papules and pustules showed greater reduction in the inocoterone-treated subjects than in the subjects treated with vehicle. This difference achieved statistical significance by week 12 (24% reduction vs 10%) and week 16 (26% reduction vs 13%) and, with longitudinal analysis, throughout the course of the study. Global assessments and changes in comedo counts and sebum excretion rates were not significantly different between the groups. No serious adverse reactions were encountered. Conclusions.— In this double-blind study of 126 male subjects with acne, a topical solution of the antiandrogen inocoterone, compared with vehicle, produced a modest but statistically significant reduction in the number of inflammatory acne lesions. ( Arch Dermatol. 1992;128:1197-1200)

Objective: To evaluate the efficacy and tolerability of 2 widely used topical α-hydroxy acids at low concentrations, 8% glycolic acid and 8% lactic (L-isoform) acid creams, in the treatment of photodamaged skin. Design: A single-center, 22-week, double-blind, vehicle-controlled, randomized clinical trial assessed the overall severity of photodamage on the faces and forearms of volunteers, based on 7 individual clinical components of cutaneous photodamage. Setting: The study was performed in an outpatient clinical research unit at the Massachusetts General Hospital, Boston. Patients: Seventy-four women, aged 40 to 70 years, with moderately severe photodamaged facial skin were enrolled in the study. One subject withdrew from the study early because of skin irritation, and 6 subjects withdrew from the study for personal reasons. Interventions: Glycolic acid, L-lactic acid, or vehicle creams were applied twice daily to the face and outer aspect of the forearms. Main Outcome Measures: Improvement in α-hydroxy acid—treated photodamaged skin as determined by patient self-assessments and physician evaluations of efficacy and irritancy. Results: The percentage of patients using either 8% glycolic acid or 8% L-lactic acid creams on the face achieving at least 1 grade of improvement (using a scale from 0 through 9) in overall severity of photodamage was significantly greater than with the vehicle cream (76% glycolic acid, 71% lactic acid, and 40% vehicle; P P P P P P Conclusions: Topical 8% glycolic acid and 8% L-lactic acid creams are modestly useful in ameliorating some of the signs of chronic cutaneous photodamage. These agents are well tolerated and available without prescription. (Arch Dermatol 1996;132:631-636)

• There are many cutaneous abnormalities in the disorder consisting of mental retardation, broad thumbs and great toes, and characteristic facies known as the Rubinstein-Taybi syndrome. The findings highlighted in this case report are numerous and include, particularly, a tendency to form keloids, hypertrichosis, unusual dermatoglyphics, seborrheic dermatitis, and a possible increased susceptibility to dermatophyte infection. (Arch Dermatol1981;117:504-506)