1. Fatal cytotoxic cutaneous lymphoma presenting as ulcerative psoriasis
- Author
-
Rokea A. el-Azhary, Mark R. Pittelkow, Nneka I. Comfere, Javier Alonso-Llamazares, Mark D. P. Davis, Lawrence E. Gibson, and Roger H. Weenig
- Subjects
Pathology ,medicine.medical_specialty ,Mycosis fungoides ,Fatal outcome ,Skin Neoplasms ,business.industry ,Cancer ,Dermatology ,General Medicine ,Middle Aged ,medicine.disease ,Cutaneous lymphoma ,Lymphoma ,Lymphoma, T-Cell, Cutaneous ,Fatal Outcome ,Psoriasis ,Skin Ulcer ,medicine ,Cytotoxic T cell ,Humans ,business ,Skin lesion ,Aged - Abstract
Background Psoriasis is a common, nonulcerative skin disorder. Observations We describe 3 men recently referred to our institution for evaluation and treatment of severe, ulcerative psoriasis that ultimately was determined to be aggressive, cytotoxic, cutaneous lymphoma. Each had a history of relatively indolent, nonulcerative patches and plaques (duration, 2-45 years) that changed to ulcerated lesions; these rapidly progressed and eventuated in death. Conclusions The clinical characteristics of the skin lesions and the histopathologic findings form a distinct and rare presentation of cutaneous lymphoma. The initial course is similar to that of mycosis fungoides but eventuates in a highly aggressive disease with fatal outcome.
- Published
- 2009