1. 0224: Prevalence and prognostic significance of left-sided valvular thickening in patients with systemic light-chain amyloidosis
- Author
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Vincent Petitalot, Arnaud Jaccard, Sarah Pradel, Victor Aboyans, Julien Magne, Najmeddine Echahidi, David Lavergne, Nicole Darodes, Dania Mohty, and Thibaud Damy
- Subjects
medicine.medical_specialty ,business.industry ,Amyloidosis ,Mean age ,Immunoglobulin light chain ,medicine.disease ,Left sided ,Internal medicine ,Cardiology ,Medicine ,In patient ,Functional status ,Thickening ,business ,Cardiology and Cardiovascular Medicine ,Endocardium - Abstract
BackgroundCardiac involvement is frequent in systemic light chain amyloidosis (AL). Left-sided valvular thickening (LVT) have been described in AL reflecting heavy infiltration of the valvular endocardium by amyloid proteins. However, the exact prevalence at diagnosis and the prognostic significance of LVT in AL patients have never been investigated.Aimsto study the prevalence and the impact on long-term survival LVT in AL patients.Methods and resultsBetween 1998 and 2013, 150 AL patients were included at diagnosis (mean age was 68±11 ans, 59% were male). A comprehensive transthoracic echocardiography was performed at baseline. The presence of LVT was assessed visually and was found in 42% of patients. Compared to patients without LVT, those with LVT have more frequently advanced NYHA functional class. They also had significantly higher left ventricular (LV) wall thickening (p=0.01), LV mass (p=0.02), and mitral E/e’ (p=0.0009) and larger left atrial size (p
- Published
- 2015
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