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We assessed quality of life in children after liver transplantation (LT) for at least 5years and in their parents, taking into account the physical, psychological, and social components, then compared the results of the patients with those of the general population and investigated the association between quality of life and somatic and psychosocial factors. Thirty-three patients, aged 8 to 18years and with a mean follow-up of 11.4years were included. Quality of life was assessed using generic self-administered questionnaires in 3 versions depending on age (pre-teens, teens, parents): the AUQUEI, OK Ado, and SQLP, respectively. Patient quality of life improved with age for all components and adolescent patients could exceed that of the general population. There was a negative impact of LT on parental quality of life, but family cohesion was strengthened. The parameters associated with patient quality of life were primarily psychosocial parameters, with special consideration for siblings and school. The somatic parameters related to LT had little impact on the quality of life of the patients but were strongly correlated with parental scores, especially when there were complications related to LT or immunosuppression. Quality-of-life assessment is complementary to clinical and laboratory data and is essential to optimize patient monitoring. Parental assessment is essential because of the long-term impact of LT on these families. A regular assessment of the quality of life of young liver transplant recipients is necessary to determine whether the encouraging results are confirmed on a larger cohort., (Copyright © 2012. Published by Elsevier SAS.)