1. Synthesis and anticancer activity of 13-membered cyclic enediynes
- Author
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Mukul Sharma, Diwan S. Rawat, Vineet Kumar, Mukesh C. Joshi, and Sanjay V. Malhotra
- Subjects
Male ,Chemistry ,Stereochemistry ,Melanoma ,Pharmaceutical Science ,Tumor cells ,Antineoplastic Agents ,medicine.disease ,Human tumor ,Leukemia ,medicine.anatomical_structure ,Cell culture ,Prostate ,Cell Line, Tumor ,Neoplasms ,Drug Discovery ,medicine ,Enediyne ,Cancer research ,Tumor Cells, Cultured ,Humans ,Female ,Drug Screening Assays, Antitumor ,Enediynes - Abstract
We herein describe the synthesis of 15 novel 13-membered cyclic enediyne derivatives using simple and straightforward approach. Representative examples were screened for their anticancer activities on 60 different human tumor cell lines representing various histologies viz. leukemia, melanoma, and cancers of lung, colon, kidney, ovary, breast, prostate, and central nervous system. The enediyne derivatives with halogen substitutions, especially fluorides were found to be active against most of the cell lines. The initial results indicates marginal to good inhibition for the growth of tumor cells for several cell lines, which shows the potential of these class of compound towards anticancer application.
- Published
- 2010