Search

Your search keyword '"Lajos Dr Szabo"' showing total 1 results
Start Over Author "Lajos Dr Szabo" Journal archiv der pharmazie
1 results on '"Lajos Dr Szabo"'

1. Synthesis of vinca alkaloids and related compounds, Part XCVI[1] Nitration study of vinblastine-type bisindole alkaloids

Author

Hedvig Bölcskei, Marianna Mák, Baitz‐Gacs Eszter, Csaba Szántay, and Lajos Dr Szabo

Subjects
Vincristine, Vinca, biology, Stereochemistry, Alkaloid, Pharmaceutical Science, Biological activity, biology.organism_classification, Chemical synthesis, Vinblastine, chemistry.chemical_compound, chemistry, Nitration, Drug Discovery, medicine, Potency, medicine.drug
Abstract

The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-9) M). 5b also showed potency in the screen for colon cancer and leukemia.

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results