1. Toolbox for Antibiotics Discovery from Microorganisms
- Author
-
Till F. Schäberle and Katja M. Fisch
- Subjects
0301 basic medicine ,Drug ,010405 organic chemistry ,medicine.drug_class ,business.industry ,Drug discovery ,Microorganism ,media_common.quotation_subject ,Antibiotics ,Pharmaceutical Science ,Computational biology ,Biology ,01 natural sciences ,Genome ,Toolbox ,0104 chemical sciences ,Biotechnology ,03 medical and health sciences ,030104 developmental biology ,Drug Discovery ,medicine ,Genome mining ,Heterologous expression ,business ,media_common - Abstract
Microorganisms produce a vast array of biologically active metabolites. Such compounds are applied by humans to positively influence their health and, therefore, natural products serve as drug leads for pharmaceutical and medicinal chemistry. In this minireview, tools for the discovery and the production of potential drug leads are explained. A snapshot is provided, starting from the isolation of new producer strains, across genomic mining of (meta)genomes to identify biosynthetic gene clusters corresponding to natural products, toward heterologous expression to produce potential drug leads.
- Published
- 2016