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Start Over Author "Hanan H. Georgey" Journal archiv der pharmazie
1 results on '"Hanan H. Georgey"'

1. New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity

Author

Yomna I. El‐Gazzar, Heba R. Ghaiad, Ahmed M. El Kerdawy, Riham F. George, Hanan H. Georgey, Khairia M. Youssef, and Hussein I. El‐Subbagh

Subjects
Drug Discovery, Pharmaceutical Science
Abstract

New 2-mercapto-quinazolin-4-one analogs were synthesized and tested for their in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth factor tyrosine kinase (EGFR-TK) inhibition activities. Compound 24, which is characterized by a 2-benzyl-thio function, showed broad-spectrum anticancer activity with high safety profile and selectivity index. The concentrations of 24 causing 50% growth inhibition (GI

Published
2022

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