1. Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity.
- Author
-
Hegazy GH, Taher A, and El-Zaher AA
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Anti-Inflammatory Agents, Non-Steroidal chemistry, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Edema drug therapy, Female, Male, Mice, Molecular Structure, Pain drug therapy, Pain Measurement, Rats, Structure-Activity Relationship, ortho-Aminobenzoates adverse effects, ortho-Aminobenzoates chemistry, ortho-Aminobenzoates therapeutic use, Anti-Inflammatory Agents, Non-Steroidal chemical synthesis, ortho-Aminobenzoates chemical synthesis
- Abstract
New derivatives related to floctafenine were synthesized and representative examples were screened for their anti-inflammatory and analgesic activities. All compounds tested were found to exhibit anti-inflammatory and analgesic activities and some were more potent than the references, floctafenine and indomethacin, in carragenan-induced rat's paw edema. None of the tested compounds showed an ulcerogenic effect on the p-benzoquinone-induced writhing test in mice.
- Published
- 2005
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