Search

Background and Aim Among the plants with multiple healing properties and a long and common history of use in Iranian traditional medicine, is dog-rose plant with the scientific name of “Rosa canina” that belongs to the Rosaceae family. This study aimed to review the effectiveness of Rosa canina in treatment of different body organs and tissues and emphasizes its therapeutic mechanism. Methods & Materials This is a review study. About 176 papers published from 2010 to 2018 were extracted from PubMed, Science Direct, Scopus, Google Scholar, Ovid, MagIran, and SID databases using related keywords and entered into study. Ethical Considerations Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors. Results Different studies had indicated the importance of Rosa canina as a medicinal plant protecting liver, lowering glucose and lipid levels, and having antioxidant and anti-inflammatory properties. The highest flavonoid activity in the Rosaceae family is related to Rosa canina. The use of herbal extracts in the treatment of common diseases, such as diabetes, fatty liver, urinary tract and Alzheimer's, has been recommended. Conclusion High qualitative and quantitative diversity of effective ingredients, ease of access, absence of adverse effects of consumption and endemic nature of Rosa canina plant make it necessary to use it for the control and treatment of common human diseases. [ABSTRACT FROM AUTHOR]

Background and Aim: Regarding the controversy about the effects of atorvastatin on blood glucose control and diabetes, we evaluated the effects of atorvastatin on blood glucose and insulin resistance in the present study. Materials and Methods: 88 type two diabetic patients (T2DP), were treated with anti-diabetes oral agents were enrolled in a double blind randomized clinical trial, placebo control. Then they were randomly classified into two 44 cases groups. The intervention group took atorvastatin 40 mg daily and control group took placebo for three months and fasting blood glucose (FBS), insulin resistance, HbA1c and lipid profile were measured and compared at the beginning and the end of the study. Data were analyzed using student t-test and paired t-test. Ethical Considerations: This study with research ethics code IR.ARAKMU.REC.90.108.10 has been approved by research ethics committee at Arak University of Medical Sciences. Findings: After three months, insulin, insulin resistance and HbA1c decreased significantly in the intervention group than control group, while FBS nonsignificantly decreased. Total cholesterol and LDL cholesterol (Low density Lipoprotein) were also decreased. Conclusion: It seems atorvastatin is effective to decrease FBS and insulin resistance in diabetic patients. [ABSTRACT FROM AUTHOR]

Background: Diabetes is the most common endocrine disorder that leads to hyperglycemia and hyperlipidemia. Royal jelly is as a bee-collected natural product has diverse biological properties and that is rich in natural antioxidants. The aim of this study was to investigate the effects of royal jelly on serum glucose and lipids profile in streptozotocin induced type 1 diabetic rats. Materials and Methods: In this experimental study, 40male Wistar rats were divided into 5 groups(8 in each): control, diabetic rats, Glibenclamide, and two groups of royal jelly- treated diabetic. Diabetes was induced in the rats by injection of streptozotocin (60 mg/kg b.w) intraperitoneally. The royal jelly was gavaged at doses of 100 and 200 mg/kg after streptozotocin injection for30 days. At the end of this period, levels of glucose, cholesterol, triglyceride, LDL and HDL in serum were measured. Results: Royal jelly and Glibenclamide significantly decreased the levels of glucose, cholesterol, triglyceride and LDL in diabetic rats (p<0.01). In addition, significant increase (p<0.01) in HDL level was observed in royal jelly-treating rats in comparison to the diabetic rats. Conclusion: The results indicated that royal jelly may be used effectively in controlling and attenuating the complications of diabetes. The hypoglycemic and hypolipidemic effects of royal jelly may be due to the presence of antioxidants. [ABSTRACT FROM AUTHOR]