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Background and Aim: Recently, a myokine called irisin has been discovered that affects glucose, obesity, metabolism and glucose homeostasis by browning white adipose tissue. The aim of this study was to evaluate the effect of 4 weeks of ginger supplementation on irisin, insulin resistance index and lipid profile of obese women following acentocentric and concentric activity. Materials and Methods: Forty girls with body mass index above 30 kg / m2, age 24.86 2 2.87 years, height 159.66 4 4.20 cm and weight 87.42 61 4.61 kg participated in the study. After measuring the maximum oxygen consumption of the subjects Were randomly divided into five groups of supplements and medications. The training protocol consisted of two sessions of acute eccentric and concentric activity. The supplement group consumed 2 g of ginger powder daily for 4 weeks. Blood samples were collected before and immediately after each activity. Data were analyzed using dependent t-test and one-way analysis of variance. Ethical considerations: This study was registered with IRCT201104246178N1 code in Iran Clinical Trial System and all participants received written consent to participate in the study. findings: According to the results of the statistical test on irisin, it was found that the amount of irisin, insulin of this hormone between two types of eccentric and concentric activities of all groups increased significantly and the amount of glucose decreased significantly (P<0.05).It was also found that changes in insulin resistance index between the two types of exercise in all groups had a slight and non-significant increase (P> 0.05). TG and LDL levels decreased significantly (P <0.05) and the results also showed that changes in Tcol levels between the two types of exercise groups decreased significantly (P> 0.05) and complementary groups had a significant decrease (P <0.05). Conclusion: Based on the results, it is suggested that long-term consumption of ginger along with regular exercise can be an effective treatment for lowering glucose and favorable changes in irisin, insulin resistance and lipid profile in obese women. [ABSTRACT FROM AUTHOR]

Background and Aim Among the plants with multiple healing properties and a long and common history of use in Iranian traditional medicine, is dog-rose plant with the scientific name of “Rosa canina” that belongs to the Rosaceae family. This study aimed to review the effectiveness of Rosa canina in treatment of different body organs and tissues and emphasizes its therapeutic mechanism. Methods & Materials This is a review study. About 176 papers published from 2010 to 2018 were extracted from PubMed, Science Direct, Scopus, Google Scholar, Ovid, MagIran, and SID databases using related keywords and entered into study. Ethical Considerations Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors. Results Different studies had indicated the importance of Rosa canina as a medicinal plant protecting liver, lowering glucose and lipid levels, and having antioxidant and anti-inflammatory properties. The highest flavonoid activity in the Rosaceae family is related to Rosa canina. The use of herbal extracts in the treatment of common diseases, such as diabetes, fatty liver, urinary tract and Alzheimer's, has been recommended. Conclusion High qualitative and quantitative diversity of effective ingredients, ease of access, absence of adverse effects of consumption and endemic nature of Rosa canina plant make it necessary to use it for the control and treatment of common human diseases. [ABSTRACT FROM AUTHOR]

Background and Aim: Regarding the controversy about the effects of atorvastatin on blood glucose control and diabetes, we evaluated the effects of atorvastatin on blood glucose and insulin resistance in the present study. Materials and Methods: 88 type two diabetic patients (T2DP), were treated with anti-diabetes oral agents were enrolled in a double blind randomized clinical trial, placebo control. Then they were randomly classified into two 44 cases groups. The intervention group took atorvastatin 40 mg daily and control group took placebo for three months and fasting blood glucose (FBS), insulin resistance, HbA1c and lipid profile were measured and compared at the beginning and the end of the study. Data were analyzed using student t-test and paired t-test. Ethical Considerations: This study with research ethics code IR.ARAKMU.REC.90.108.10 has been approved by research ethics committee at Arak University of Medical Sciences. Findings: After three months, insulin, insulin resistance and HbA1c decreased significantly in the intervention group than control group, while FBS nonsignificantly decreased. Total cholesterol and LDL cholesterol (Low density Lipoprotein) were also decreased. Conclusion: It seems atorvastatin is effective to decrease FBS and insulin resistance in diabetic patients. [ABSTRACT FROM AUTHOR]