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Background and Aim: Regarding the controversy about the effects of atorvastatin on blood glucose control and diabetes, we evaluated the effects of atorvastatin on blood glucose and insulin resistance in the present study. Materials and Methods: 88 type two diabetic patients (T2DP), were treated with anti-diabetes oral agents were enrolled in a double blind randomized clinical trial, placebo control. Then they were randomly classified into two 44 cases groups. The intervention group took atorvastatin 40 mg daily and control group took placebo for three months and fasting blood glucose (FBS), insulin resistance, HbA1c and lipid profile were measured and compared at the beginning and the end of the study. Data were analyzed using student t-test and paired t-test. Ethical Considerations: This study with research ethics code IR.ARAKMU.REC.90.108.10 has been approved by research ethics committee at Arak University of Medical Sciences. Findings: After three months, insulin, insulin resistance and HbA1c decreased significantly in the intervention group than control group, while FBS nonsignificantly decreased. Total cholesterol and LDL cholesterol (Low density Lipoprotein) were also decreased. Conclusion: It seems atorvastatin is effective to decrease FBS and insulin resistance in diabetic patients. [ABSTRACT FROM AUTHOR]

Background: Considering the high prevalence of diabetes and developing cardiovascular diseases through dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of oligofructose-enriched inulin on serum lipid concentrations and inflammation in women with type 2 diabetes. Materials and Methods: In this clinical trial, 52 women with type 2 diabetes were randomly assigned to one of two groups. Experimental group (n=27) received 10g/day oligofructose-enriched inulin and control group (n=25) received 10g/day maltodextrin (placebo) for 8 weeks. Dietary intakes, anthropometric indicies, hs-CRP and serum lipids levels were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-test and ANCOVA were used to compare comparison of quantitative variables. Results: At the end of study, significant decrease was observed in total cholesterol levels mean (28.00 mg/dL, 14.10%), LDL-c (22.00 mg/dL, 21.70%), TC/HDL-c ratio (0.73, 20.70%) and LDL-c/HDL-c ratio (0.55, 27.50%) in oligofructose-enriched inulin compared with the maltodextrin group (p=0.03). Changes in concentrations of triglycerides, hsCRP and high-density lipoprotein were not significant in oligofructose-enriched inulin compared to maltodextrin group. Conclusions: Oligofructose-enriched inulin supplementation with improving in inflammtion and lipid profile help in management of type 2 diabetes and its complications. [ABSTRACT FROM AUTHOR]