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Background and Aim: Recently, a myokine called irisin has been discovered that affects glucose, obesity, metabolism and glucose homeostasis by browning white adipose tissue. The aim of this study was to evaluate the effect of 4 weeks of ginger supplementation on irisin, insulin resistance index and lipid profile of obese women following acentocentric and concentric activity. Materials and Methods: Forty girls with body mass index above 30 kg / m2, age 24.86 2 2.87 years, height 159.66 4 4.20 cm and weight 87.42 61 4.61 kg participated in the study. After measuring the maximum oxygen consumption of the subjects Were randomly divided into five groups of supplements and medications. The training protocol consisted of two sessions of acute eccentric and concentric activity. The supplement group consumed 2 g of ginger powder daily for 4 weeks. Blood samples were collected before and immediately after each activity. Data were analyzed using dependent t-test and one-way analysis of variance. Ethical considerations: This study was registered with IRCT201104246178N1 code in Iran Clinical Trial System and all participants received written consent to participate in the study. findings: According to the results of the statistical test on irisin, it was found that the amount of irisin, insulin of this hormone between two types of eccentric and concentric activities of all groups increased significantly and the amount of glucose decreased significantly (P<0.05).It was also found that changes in insulin resistance index between the two types of exercise in all groups had a slight and non-significant increase (P> 0.05). TG and LDL levels decreased significantly (P <0.05) and the results also showed that changes in Tcol levels between the two types of exercise groups decreased significantly (P> 0.05) and complementary groups had a significant decrease (P <0.05). Conclusion: Based on the results, it is suggested that long-term consumption of ginger along with regular exercise can be an effective treatment for lowering glucose and favorable changes in irisin, insulin resistance and lipid profile in obese women. [ABSTRACT FROM AUTHOR]