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Shrimp aquaculture is an important industry that experiences significant losses fromVibriospecies, especially at the larval and juvenile stages. Proteinaceous virulence factors, including alkaline proteases, metalloproteases, cysteine proteases and alkaline serine proteases, have been identified as important elements inVibriopathogenesis. This review summarizes current knowledge regarding the principal pathogenicVibriospecies in shrimp, with emphasis on relevant exotoxins and their modes of action, principal characteristics and molecular database. This pathogenic factors and their relation with other molecules produced by microorganisms may be help to understand the virulence mechanisms present inVibriostrain. [ABSTRACT FROM AUTHOR]