1. In-vitro and in-vivo evaluation of strontium doped calcium phosphate coatings on biodegradable magnesium alloy for bone applications
- Author
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Omar Faruq, Andrew R. Padalhin, Preeti Makkar, Hoe Jin Kang, and Byong-Taek Lee
- Subjects
Materials science ,Biocompatibility ,Alloy ,General Physics and Astronomy ,chemistry.chemical_element ,02 engineering and technology ,engineering.material ,010402 general chemistry ,01 natural sciences ,Corrosion ,Coating ,Magnesium alloy ,Strontium ,Magnesium ,technology, industry, and agriculture ,Surfaces and Interfaces ,General Chemistry ,equipment and supplies ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,Surfaces, Coatings and Films ,Surface coating ,chemistry ,Chemical engineering ,engineering ,0210 nano-technology - Abstract
The objective of the present work was to investigate the in-vitro and in-vivo performance of strontium doped calcium phosphate (Ca-Sr-P) coatings on ZK60 magnesium (Mg) alloy for bone applications. A chemical immersion technique was employed to develop Ca-Sr-P coating on biodegradable Mg alloy. Surface morphology, chemical composition, phase, mechanical properties, wettability, in-vitro corrosion, cytocompatability, in-vivo degradation and biocompatibility of Ca-Sr-P coatings were studied. The Ca-Sr-P coating (~20 µm) exhibited a dense, crystalline, uniform, and crack-free surface. In-vitro studies revealed that the coating improved the corrosion resistance of Mg alloy and enhanced bioactivity. The surface coating also promoted the adhesion, proliferation, and osteogenic markers expression of MC3T3-E1 cells. The coating lowered the degradation rate in-vivo compared with Mg alloy. Higher bone formation and better ossteointegration was found around the coating than the Mg alloy after 4 weeks of implantation in a rabbit model. Thus, the Ca-Sr-P coating with a reduced degradation and improved biocompatibility could be used in Mg-based orthopedic implant applications.
- Published
- 2020
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