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A 3D numerical model was presented to investigate the blast-induced damage characteristics of highly stressed rock mass. The RHT (Riedel, Hiermaier, and Thoma) model in LS-DYNA was used to simulate the blast-induced damage and its parameters were calibrated by a physical model test. Based on the calibrated numerical model, the influences of confining pressure and free surface span on the blast-induced damage characteristics were investigated. The results show that under uniaxial loading, the crater volume increases with confining pressure increases. The uniaxial static load can change the optimal burden and the critical embedding depth of charge. In stressed rock, the variation law of the crater shape affected by radial tensile fractures is opposite to that affected by reflected tensile fractures. Under the biaxial static load, the crater volume of the borehole placed on the side of the max static load is greater than the other side. The explosion crater can be improved by increasing the free surface span on the same side. Finally, it is suggested that the blasting efficiency can be improved by preferentially detonating the charge on the side of the max static load, and then the charge on the other side can be detonated with a wider free surface span.