1. SARS-CoV-2: Some Aspects of Molecular Evolution, Cellular Pathogenesis, and Immune System Mechanism Elusion
- Author
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Angela Quirino, Nadia Marascio, Giorgio Settimo Barreca, Luigia Gallo, Aida Giancotti, Angelo Giuseppe Lamberti, Cinzia Peronace, Enrico Maria Trecarichi, Paolo Fusco, Maria Mazzitelli, Francesca Divenuto, Grazia Pavia, Angela Suraci, Giovanni Matera, and Maria Carla Liberto more...
- Subjects
SARS-CoV-2 ,cytokine storm ,immune system ,antibody-dependent enhancement (ADE) ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The purpose of this review is to address some of the latest aspects regarding molecular features, pathogenic mechanisms, and immune system response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on recent publications in this field from March 2020 to May 2021. Interpretation keys for periodic re-emergence of coronavirus infections and other lethal viral pandemics are suggested. Antibody-dependent enhancement (ADE) and other potential mechanisms of immune system deception are put forward. Therefore, vaccine development must take into account ADE and other unwanted side effects of immune-based medical intervention. Features reported in our review will allow both clinicians and basic science researchers to take home ideas to improve their knowledge about SARS-CoV-2. more...
- Published
- 2021
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