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Excitation functions were measured by the activation method using stacked-foil technique for the nat Sr(p,xn) 88,87m,g,86m,g Y reactions up to 18 MeV. The experimental results were compared with the theoretical data from EMPIRE-3.2 code and TENDL. Integral yields of 88,87m,g,86m,g Y were estimated based on the measured cross sections. The optimum energy range for the production of the important isotope 88 Y is Ep = 16→11 MeV, 88 Y yield amounts to about 3 MBq/µAh., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

The rapid synthesis of two radiofluoronicotinamide derivatives, namely, [ 18 F]MEL050 and [ 18 F]MEL-2F has been simply performed starting from commercial materials. [ 18 F]MEL-2F is a new, potential analogue PET-probe for melanoma imaging. [ 18 F]MEL050 is already an excellent PET imaging probe for early specific diagnosis. The synthesis involves coupling step to obtain the precursor followed by radiofluorination. During the synthesis of the precursors different coupling reagents, such as HBTU, TFFH, HOBT, COMU and PyCIU have been applied. PyClU was found the best to reduce the coupling period to < 1h. The labeled compounds were isolated and purified by HPLC. In the in-vitro study three kinds of cells, namely, Melur (melanin free), KB-3 carcinoma cell line (non-melanoma) and B16-F10 melanoma cell line were used to evaluate the uptake of the radiotracers., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Proton induced nuclear reactions were measured with stacked-foil technique on natural zirconium targets up to 16.7MeV. Excitation functions were measured for the production of (90,92m,95m,95g,96)Nb and (88)Y. Cumulative cross-section, thick target yields and activation functions were deduced and compared with the available experimental data, as well as with the nuclear models codes; ALICE-IPPE, EMPIRE and TALYS. The integral yields for thick targets were deduced from the measured excitation function of the produced radionuclides., (Copyright © 2011 Elsevier Ltd. All rights reserved.)