1. Investigation of the role of the base in the synthesis of [18F]FLT
- Author
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Suehiro, Makiko, Vallabhajosula, Shankar, Goldsmith, Stanley J., and Ballon, Douglas J.
- Subjects
- *
ELIMINATION (Mathematics) , *CORPORATIONS , *CORPORATION law , *ALGEBRA - Abstract
Abstract: The role of the base in the synthesis of 3′-deoxy-3′-[18F]fluorothymidine, [18F]FLT, via nucleophilic substitution of the nosyl group with [18F]fluoride was investigated. The rate of 18F-incorporation into the molecule dramatically changed as a function of the precursor-to-base ratio. In the presence of excess base, the precursor was consumed by elimination before substitution was complete. When the precursor-to-base ratio was optimal, an overall [18F]FLT yield of 30–40% was achieved even if the precursor amount was as small as 8–13mg. [Copyright &y& Elsevier]
- Published
- 2007
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