1. Substituent effect on the yield of unpaired electrons in DNA bases studied by electron paramagnetic resonance
- Author
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Kentaro Fujii, Tsutomu Sekine, Toshitaka Oka, Yasushi Kino, and Akinari Yokoya
- Subjects
Physics and Astronomy (miscellaneous) ,Pyrimidine ,Substituent ,Electron ,Ring (chemistry) ,Photochemistry ,01 natural sciences ,Nucleobase ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,Unpaired electron ,law ,030220 oncology & carcinogenesis ,Yield (chemistry) ,0103 physical sciences ,010306 general physics ,Electron paramagnetic resonance - Abstract
The physicochemical processes underlying the radiation sensitization of DNA by the K-shell photoabsorption of nitrogen and oxygen atoms are unclear. Accordingly, we evaluated electron paramagnetic resonance spectra of thin films of pyrimidine bases. By altering the substituents of the pyrimidine ring, we found a substituent effect on the yield of unpaired electrons induced by photoabsorption. The yield of the unpaired electrons of the DNA-base containing amino groups increased by the donation of electrons, and the yield of halogenated DNA-bases decreased by the withdrawal of electrons. These different physicochemical processes might affect DNA bases, leading to differences in DNA modification.
- Published
- 2018