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TIn this present study, the forced convection heat transfer performance of different fluids, namely, Al2O3-water, and CuO-water nanofluid has been studied experimentally in an automobile radiator. Three different concentration of nanofluid in the range of 0-1.0 vol.% have been prepared by addition of Al2O3 and CuO nanoparticles into water. The test fluid flow rate can be varied in the range of 2 l/min to 5 l/min to have a fully turbulent regime. Obtained results demonstrate that the fluid circulating rate can improve the heat transfer performance. The heat transfer performance of CuO-water nanofluid was found better than the other heat transfer fluids. Furthermore, the Nusselt number is found to increase with the increase in the nanoparticle concentration and nanofluid velocity.