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A class of multi-objective fractional semi-infinite optimization problems with uncertain data were investigated. Firstly, a robust optimization model corresponding to the uncertain multi-objective optimization problem was introduced. Then the optimization model was converted to a multi-objective optimization problem with the Dinkelbach method. In turn, by means of the scalarization method, the corresponding scalarization optimization problem was built, and the relationship between robust solutions to the multi-objective optimization problem and its corresponding scalarization optimization problem was described. Finally, through a robust-type sub-differential constraint qualification, the robust optimality condition for approximate quasi-efficient solutions to the multi-objective fractional optimization problem was established. [ABSTRACT FROM AUTHOR]