Search

Your search keyword '"Jakki C. Cooney"' showing total 1 results
Start Over Author "Jakki C. Cooney" Journal applied and environmental microbiology
1 results on '"Jakki C. Cooney"'

1. Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci

Author

R. Paul Ross, Jennifer Garry, Marianne Horgan, Aidan Coffey, Olivia McAuliffe, Gerald F. Fitzgerald, Gary O’Flynn, and Jakki C. Cooney

Subjects
Staphylococcus, CHAP domain, Lysin, Staphylococcal infections, medicine.disease_cause, Applied Microbiology and Biotechnology, Microbiology, Bacteriophage, Bacteriolysis, Mucoproteins, Drug Resistance, Bacterial, medicine, Bacteriophages, Sequence Deletion, Ecology, biology, Amidohydrolase, Autolysin, Staphylococcal Infections, medicine.disease, biology.organism_classification, Physiology and Biotechnology, Virology, Anti-Bacterial Agents, Lytic cycle, Staphylococcus aureus, Food Science, Biotechnology
Abstract

A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus . This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results