1. Absence of transformation of beta-muricholic acid by human microflora implanted in the digestive tracts of germfree male rats
- Author
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P M Raibaud, Danièle Gadelle, M J Riottot, E C Sacquet, Laboratoire d'écologie microbienne, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration
- Subjects
Male ,medicine.medical_specialty ,Chromatography, Gas ,medicine.drug_class ,Cholic Acid ,Biology ,Applied Microbiology and Biotechnology ,chemistry.chemical_compound ,Feces ,fluids and secretions ,Internal medicine ,medicine ,polycyclic compounds ,Animals ,Germ-Free Life ,Humans ,Biotransformation ,[SDV.EE]Life Sciences [q-bio]/Ecology, environment ,Ecology ,Bile acid ,Bacteria ,Germ-free animal ,Deoxycholic acid ,Cholic acid ,Cholic Acids ,Metabolism ,Rats ,[SDV.EE] Life Sciences [q-bio]/Ecology, environment ,Transformation (genetics) ,Endocrinology ,chemistry ,RAT ,Digestive tract ,Female ,Digestive System ,Food Science ,Biotechnology ,Deoxycholic Acid ,Research Article - Abstract
Germfree rats biosynthetize cholic and beta-muricholic acids. The latter does not exist in humans. Germfree rats were given human fecal suspensions. These rats degraded cholic acid into deoxycholic acid but failed to metabolize beta-muricholic acid.
- Published
- 1984