9 results on '"B, Mark Smithers"'
Search Results
2. Trends and patterns of care of sentinel node biopsy in cutaneous melanoma: a <scp>population‐based</scp> study in <scp>Queensland</scp>
- Author
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Jessica Wong, Julie Moore, H. Peter Soyer, Victoria Mar, and B. Mark Smithers
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Surgery ,General Medicine - Published
- 2023
3. Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population‐level study
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Joanne F. Aitken, Theodore Sklavos, Kevin Tian, Peter D. Baade, Brandon Leggett, Aaditya Narendra, Jonathan Fawcett, Callum Leggett, and B. Mark Smithers
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medicine.medical_specialty ,Esophageal Neoplasms ,Population level ,medicine.medical_treatment ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,medicine ,Overall survival ,Humans ,business.industry ,Australia ,Cancer ,General Medicine ,Perioperative ,medicine.disease ,Hospitals ,Surgery ,Esophagectomy ,Low volume ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Queensland ,Outcome data ,business ,Cancer surgery - Abstract
Background: The impact of hospital characteristics on the quality of surgery and survival following oesophagogastric cancer surgery has not been well established in Australia. We assessed the interaction between hospital volume, service capability and surgical outcomes, with the hypothesis that both the quality of surgery and survival are better following treatment in high-volume, high service capability hospitals. Methods: All patients undergoing oesophagectomy and gastrectomy for cancer in Queensland, between 2001 and 2015, were included. Demographic, pathology and outcome data were collected. Hospitals were categorized into high (HV) (≥5 gastrectomies; ≥6 oesophagectomies) and low volume (LV). Hospital service capability was defined as high (HS) and low (LS), and then linked to hospital volume: HVHS, LVHS and LVLS. Higher quality surgery was defined using six perioperative parameters. Univariable comparisons of quality of surgery between hospital groups used chi-squared tests. The 5-year overall survival was compared using log-rank tests and Cox proportional hazard models. Results: For both gastrectomy and oesophagectomy, higher quality surgery occurred more frequently in HVHS hospitals (gastrectomy: HVHS = 44.2%, LVHS = 23.1%, LVLS = 29.1% (P < 0.01); oesophagectomy: HVHS = 34.5%, LVHS = 24.4%, LVLS = 21.7% (P = 0.01)). Following oesophagectomy, the 3- and 5-year overall survival was better following treatment in HVHS (P < 0.01). There was no difference between the groups following gastrectomy. Conclusion: In Queensland, the quality of surgery was higher in HVHS hospitals performing gastrectomy and oesophagectomy; however, the impact on cancer survival was only seen following oesophagectomy.
- Published
- 2020
4. Regional nodal metastasis and 5‐year survival in patients with thin melanoma in Queensland: a population‐based study
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B. Mark Smithers, Catherine E. Forristal, Julie Moore, Harrison Theile, Adèle C. Green, Danica Cossio, and Nathan Dunn
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Male ,Oncology ,medicine.medical_specialty ,Skin Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,Melanoma ,Aged ,Neoplasm Staging ,Cancer staging ,Sentinel Lymph Node Biopsy ,business.industry ,Nodal metastasis ,Cancer ,General Medicine ,Prognosis ,medicine.disease ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Cohort ,Cutaneous melanoma ,030211 gastroenterology & hepatology ,Surgery ,Queensland ,Lymph ,Neoplasm Recurrence, Local ,business - Abstract
Optimal management of regional lymph nodes for thin cutaneous melanoma is uncertain. We evaluated regional lymph node involvement and 5-year melanoma-specific survival (MSS) in patients with thin (≤1 mm) primary melanoma.Patients with a melanoma, American Joint Committee on Cancer Staging 8th Edition pT1a (0.8 mm) or pT1b (ulceration; and/or 0.8-1.0 mm), diagnosed during 2001-2015 were identified from the Queensland Oncology Repository. We extracted demographic, pathology and clinical details, including sentinel lymph node biopsy (SLNB), regional nodal dissection and nodal recurrence. Poisson regression was used to assess recurrence risk in patients who did not undergo SLNB. The 5-year MSS was calculated using the Kaplan-Maier method with Cox regression to compare survival outcomes according to SLNB performance.Of the 27 824 eligible patients, 240 (0.9%) underwent SLNB. One hundred and seventy-eight patients (0.6%) without SLNB had nodal recurrence. Of the 4848 patients with a pT1b lesion, 166 (3.4%) had SLNB with 12 (7.2%) positive; of the remainder, 99 (2.1%) had clinical recurrence. Risk of recurrence was higher in males, nodular subtype and T1b lesions and lower if patients were aged60 years. The 5-year MSS was similar for observed and SLNB cohorts (99.66% versus 98.92%) but worse for T1b lesions (98.90%) and clinical nodal recurrence (66.89%).Overall prognosis for T1 melanoma is excellent with nodal involvement being rare. However, the American Joint Committee on Cancer 8th Edition T1b melanoma correlates with significantly worse 5-year MSS and increased regional nodal recurrence (notably for 0.8-1.0 mm lesions with ulceration). Further characterization of high-risk groups for nodal positivity that impacts patient outcome is needed for the pT1 melanoma cohort.
- Published
- 2020
5. New treatment paradigms for clinically apparent metastatic melanoma in regional lymph nodes
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John Spillane, Andrew J. Spillane, T. Michael Hughes, Michael A. Henderson, B. Mark Smithers, and John F. Thompson
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medicine.medical_specialty ,Skin Neoplasms ,Metastatic melanoma ,medicine.medical_treatment ,Biopsy, Fine-Needle ,Neoplasm Recurrence ,Biopsy ,medicine ,Humans ,Melanoma ,Neoplasm Staging ,medicine.diagnostic_test ,Sentinel Lymph Node Biopsy ,business.industry ,Australia ,General Medicine ,Immunotherapy ,medicine.disease ,Practice Guidelines as Topic ,Surgery ,Neoplasm staging ,Lymph Nodes ,Radiology ,Lymph ,Neoplasm Recurrence, Local ,business - Published
- 2019
6. Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma
- Author
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Christopher Paul Allan, Andrew Barbour, Michael Wagels, Jane E. Theodore, B. Mark Smithers, Adam Frankel, Janine Thomas, and Gerard Bayley
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medicine.medical_specialty ,medicine.diagnostic_test ,Groin ,business.industry ,Melanoma ,Sentinel lymph node ,General Medicine ,Dissection (medical) ,030230 surgery ,medicine.disease ,Surgery ,body regions ,03 medical and health sciences ,Axilla ,0302 clinical medicine ,medicine.anatomical_structure ,Surgical oncology ,030220 oncology & carcinogenesis ,Biopsy ,Medicine ,business ,Lymph node - Abstract
BackgroundThis study assessed and compared the morbidity of nodal dissection in the axilla and groin including sentinel lymph node biopsy (SLNB), completion lymph node dissection for a positive SLNB (CLND) and therapeutic lymph node dissection (TLND) with and without adjuvant radiotherapy (RT).
- Published
- 2016
7. Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma
- Author
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Jane E, Theodore, Adam J, Frankel, Janine M, Thomas, Andrew P, Barbour, Gerard J, Bayley, Christopher P, Allan, Michael, Wagels, and B Mark, Smithers
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Adult ,Male ,Skin Neoplasms ,Sentinel Lymph Node Biopsy ,Middle Aged ,Lymphatic Metastasis ,Axilla ,Humans ,Lymph Node Excision ,Female ,Queensland ,Morbidity ,Melanoma ,Aged ,Follow-Up Studies ,Forecasting ,Neoplasm Staging ,Retrospective Studies - Abstract
This study assessed and compared the morbidity of nodal dissection in the axilla and groin including sentinel lymph node biopsy (SLNB), completion lymph node dissection for a positive SLNB (CLND) and therapeutic lymph node dissection (TLND) with and without adjuvant radiotherapy (RT).Patients who had nodal dissection in the axilla or groin for cutaneous melanoma over an 18-year period (1995-2013) were prospectively documented on a database. The median follow-up was nearly 3 years. Early complications and clinically relevant lymphoedema were retrospectively analysed to assess the incidence and differences between the region and type of nodal surgery.Included were 1521 patients following nodal dissection in the axilla (916 patients) and groin (605 patients). Less early complications occurred following SLNB in the axilla compared with the groin (5% versus 14%, P = 0.0001). Early complications were similar for CLND and TLND in the groin (49% versus 43%, P = 0.879) and axilla (28% versus 33%, P = 0.607). Moderate to severe lymphoedema rates were similar following axillary SLNB and CLND (6% versus 8%, P = 0.407). The lymphoedema rate for groin SLNB was lower than CLND (10% versus 20%, P = 0.063). No significant difference in lymphoedema rates followed CLND and TLND in each region. Following TLND, RT increased lymphoedema rates.Morbidity may occur following SLNB with the groin having a higher rate of early complications and lymphoedema compared with the axilla. The morbidity following CLND and TLND were similar. Lymphoedema rates were increased following RT.
- Published
- 2015
8. Desmoplastic melanoma: the role of radiotherapy in improving local control
- Author
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B. Mark Smithers, Bryan Burmeister, Elizabeth Burmeister, Gerard Bayley, and Matthew Foote
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Internal medicine ,medicine ,Humans ,neoplasms ,Melanoma ,Survival analysis ,Aged ,Retrospective Studies ,Desmoplastic melanoma ,Aged, 80 and over ,business.industry ,Incidence (epidemiology) ,Distant metastasis ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Survival Analysis ,Surgery ,Radiation therapy ,Cutaneous melanoma ,Female ,Radiotherapy, Adjuvant ,Neoplasm Recurrence, Local ,business - Abstract
Desmoplastic melanoma (DM) is a rare subtype of cutaneous malignant melanoma reported to have a high local recurrence rate with surgical excision alone. The incidence of regional and distant metastasis is considered to be lower than traditional cutaneous melanoma, warranting more aggressive treatment of local disease. We conducted a retrospective analysis of patients with DM treated through the Princess Alexandra Hospital Melanoma Clinic to address the role of radiotherapy in the local control of this tumour.A review of a clinical database identified 24 patients between January 1997 and March 2006 with histopathologically confirmed DM who had received surgical excision as initial treatment followed by postoperative radiotherapy. All histopathology reports and radiotherapy treatment plans were reviewed. The primary outcome measure was 3-year in-field relapse-free survival.There were 24 patients with 22 having a DM in the head and neck region. The median tumour thickness was 5.2 mm. The histopathological margin was less than 10 mm in 17 (71%) of patients. The 3-year in-field relapse-free survival was 91% (95% confidence interval 68.1-97.6%), the 3-year relapse-free survival was 86% (95% confidence interval 63.2-95.4%) with a 3-year overall survival of 83% (95% confidence interval 54.9-94.3%).In a selected series of patients with DM with a high risk of local recurrence, adjuvant radiotherapy may have been effective in reducing the rate of local recurrence after surgical resection. A randomized trial is currently being developed to confirm this possible benefit.
- Published
- 2008
9. EMERGENCY RIGHT HEMICOLECTOMY IN COLON CARCINOMA: A PROSPECTIVE STUDY
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Neville C. Davis, David E. Theile, E. Evans, B. Mark Smithers, and Jon R. Cohen
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Male ,medicine.medical_specialty ,Perforation (oil well) ,Anastomosis ,Postoperative Complications ,Colon carcinoma ,Carcinoma ,Humans ,Medicine ,Prospective Studies ,Elective surgery ,Prospective cohort study ,Aged ,business.industry ,General surgery ,Age Factors ,General Medicine ,medicine.disease ,Surgery ,Colonic Neoplasms ,Curative surgery ,Female ,Emergencies ,business ,Right hemicolectomy - Abstract
The morbidity and mortality in right hemicolectomy for carcinoma of the colon is examined, with particular attention to the influence of emergency surgery and advanced disease. Of the 244 patients who had surgery, 57 required emergency surgery and 187 elective surgery. The overall mortality was 5.7% with no difference statistically between the elective and emergency groups. Anastomotic complications were significantly greater in the groups undergoing emergency resection and elective palliative surgery when compared with elective curative surgery. All patients with advanced disease had a higher morbidity and mortality, both in elective and emergency surgery. The factors most important in relation to mortality and morbidity were thus advanced disease, advanced age and cardiorespiratory complications. This being the case, it is felt that the present management of emergency right hemicolectomy with anastomosis should continue to be the treatment of choice for obstructing or perforated carcinomas of the right colon.
- Published
- 1986
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