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Start Over Author "Karin C. S. Chen Liu" Journal antiviral research
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1. Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix

Author

Shoei-Sheng Lee, Feng Lin Hsu, Chia Wen Chang, Mei Tsu Lin, Jung-Yaw Lin, and Karin C. S. Chen Liu

Subjects
ved/biology.organism_classification_rank.species, Lignans, Structure-Activity Relationship, chemistry.chemical_compound, Virology, Humans, Tannin, Polymerase, Pharmacology, Lignan, chemistry.chemical_classification, biology, Phyllanthus myrtifolius, ved/biology, RNA-Directed DNA Polymerase, DNA Polymerase II, biology.organism_classification, HIV Reverse Transcriptase, Reverse transcriptase, Castanopsis hystrix, Kinetics, Enzyme, Biochemistry, chemistry, biology.protein, Reverse Transcriptase Inhibitors, Tannins, Drugs, Chinese Herbal
Abstract

Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-alpha (HDNAP-alpha) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 microM for HIV-1 RT, and 289 and 989 microM for HDNAP-alpha, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT.

Published
1995
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