1. HNO signaling mechanisms.
- Author
-
Fukuto JM and Carrington SJ
- Subjects
- Animals, Humans, Metalloproteins chemistry, Metalloproteins metabolism, Nitrogen Oxides metabolism, Signal Transduction, Sulfhydryl Compounds chemistry, Sulfhydryl Compounds metabolism, Nitrogen Oxides chemistry
- Abstract
Due to recent discoveries of important and novel biological activity, nitroxyl (HNO) has become a molecule of significant interest. Although it has been used in the past as a treatment for alcoholism, it is currently being touted as a treatment for heart failure. It is becoming increasingly clear that many of the biological actions of HNO can be attributed to its ability to react with specific thiol- and, possibly, heme-proteins. Herein is discussed the chemistry of HNO with likely biological targets. A particular focus is given to targets associated with the pharmacological utility of HNO as a cardiovascular agent and for the treatment of alcoholism.
- Published
- 2011
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