1. Chocolate Consumers and Lymphocyte-to-Monocyte Ratio: A Working Hypothesis from a Preliminary Report of a Pilot Study in Celiac Subjects
- Author
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Anna Raguzzini, Giovanna Poce, Mariangela Biava, Sara Consalvi, Ilaria Peluso, Francesca Palmacci, and Elisabetta Toti
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Physiology ,diet ,immunity ,inflammation ,Iron absorption ,Lymphocyte ,Clinical Biochemistry ,030204 cardiovascular system & hematology ,Dark chocolate ,Biochemistry ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,food ,Red Blood Cell Count ,Preliminary report ,Internal medicine ,medicine ,Molecular Biology ,Mean corpuscular volume ,030109 nutrition & dietetics ,medicine.diagnostic_test ,business.industry ,Monocyte ,Communication ,lcsh:RM1-950 ,Cell Biology ,food.food ,medicine.anatomical_structure ,lcsh:Therapeutics. Pharmacology ,Hemoglobin ,business - Abstract
Background and aim: The aim of this work was to evaluate the relationship between platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) with habitual consumption of dark chocolate in a group of celiac subjects in which chocolate consumption and lower neutrophil-to-lymphocyte ratio (NLR) association had already been observed. Additionally, due to the known anti-nutrient effect on iron absorption, we evaluated red blood cell count (RBC), mean corpuscular volume (MCV) and hemoglobin (Hb) values. Methods: Chocolate consumers and non-consumers were matched for sex, menopausal status, NLR values over the previously suggested cut off (2.32) for celiac patients, and co-morbidities. Results: Chocolate consumers had high LMR compared to non-consumers, whereas no differences were observed between chocolate consumers and non-consumers in RBC, MCV, Hb and PLR. However, similar number of subjects had PLR higher than the previously suggested cut off (143.7) for celiac disease. Conclusions: This preliminary report suggests a working hypothesis for larger studies aimed at establishing cut off values for LMR in celiac patients and the modulation of this marker by dietary antioxidants.
- Published
- 2019