1. Escherichia coli Sequence Type 457 Is an Emerging Extended-Spectrum-β-Lactam-Resistant Lineage with Reservoirs in Wildlife and Food-Producing Animals
- Author
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Khin Chaw, Ibrahim Bitar, Ethan R. Wyrsch, Steven P. Djordjevic, Kristina Nesporova, Monika Dolejska, Adam Valcek, Jaroslav Hrabak, Patrick N A Harris, Ivan Literak, Faculty of Medicine and Pharmacy, and Department of Bio-engineering Sciences
- Subjects
Lineage (evolution) ,Animals, Wild ,ST457 ,Biology ,medicine.disease_cause ,infectious diseases ,beta-Lactams ,beta-Lactamases ,Epidemiology and Surveillance ,03 medical and health sciences ,Plasmid ,medicine ,Escherichia coli ,Animals ,Humans ,AmpC ,Pharmacology (medical) ,Clade ,Gene ,Escherichia coli Infections ,Phylogeny ,030304 developmental biology ,Genetics ,ExPEC ,0303 health sciences ,Phylogenetic tree ,030306 microbiology ,Australia ,Anti-Bacterial Agents ,Phylogenetic diversity ,ESBL ,I1 plasmids ,Mobile genetic elements ,pharmacology ,Plasmids - Abstract
Silver gulls carry phylogenetically diverse Escherichia coli, including globally dominant extraintestinal pathogenic E. coli (ExPEC) sequence types and pandemic ExPEC-ST131 clades; however, our large-scale study (504 samples) on silver gulls nesting off the coast of New South Wales identified E. coli ST457 as the most prevalent. A phylogenetic analysis of whole-genome sequences (WGS) of 138 ST457 samples comprising 42 from gulls, 2 from humans (Australia), and 14 from poultry farmed in Paraguay were compared with 80 WGS deposited in public databases from diverse sources and countries. E. coli ST457 strains are phylogenetic group F, carry fimH145, and partition into five main clades in accordance to predominant flagella H-antigen carriage. Although we identified considerable phylogenetic diversity among the 138 ST457 strains, closely related subclades (
- Published
- 2020