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Start Over Author "Neftel K" Journal antimicrobial agents and chemotherapy
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2. Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro.

Author

Cottagnoud P, Acosta F, Cottagnoud M, Neftel K, and Täuber MG

Subjects
Animals, Anti-Infective Agents cerebrospinal fluid, Anti-Infective Agents pharmacology, Ceftriaxone cerebrospinal fluid, Ceftriaxone pharmacology, Cephalosporins cerebrospinal fluid, Cephalosporins pharmacology, Cephalosporins therapeutic use, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Meningitis, Pneumococcal cerebrospinal fluid, Meningitis, Pneumococcal microbiology, Microbial Sensitivity Tests, Naphthyridines cerebrospinal fluid, Naphthyridines pharmacology, Penicillin Resistance, Pneumococcal Infections cerebrospinal fluid, Pneumococcal Infections microbiology, Rabbits, Streptococcus pneumoniae drug effects, Anti-Infective Agents therapeutic use, Ceftriaxone therapeutic use, Fluoroquinolones, Meningitis, Pneumococcal drug therapy, Naphthyridines therapeutic use, Pneumococcal Infections drug therapy
Abstract

The bactericidal activities of monotherapy with trovafloxacin (-0.37 +/- 0.15 Delta log(10) CFU/ml. h), vancomycin (-0.32 +/- 0.12 Delta log(10) CFU/ml. h), and ceftriaxone (-0.36 +/- 0.19 Delta log(10) CFU/ml. h) for the treatment of experimental meningitis in rabbits due to a clinical penicillin-resistant pneumococcal strain (MIC, 4 mg/liter) were similar. The combination of ceftriaxone with trovafloxacin considerably improved the killing rates (-0.67 +/- 0.16 Delta log(10) CFU/ml. h) and was slightly superior to ceftriaxone with vancomycin (killing rate, -0.53 +/- 0. 22 Delta log(10) CFU/ml. h), the regimen most commonly used in clinical practice. In vitro, synergy was demonstrated between ceftriaxone and trovafloxacin by the checkerboard method (fractional inhibitory concentration index, 0.5) and by time-killing assays over 8 h.

Published
2000
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3. Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model.

Author

Rodoni D, Hänni F, Gerber CM, Cottagnoud M, Neftel K, Täuber MG, and Cottagnoud P

Subjects
Animals, Anti-Bacterial Agents cerebrospinal fluid, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Anti-Infective Agents cerebrospinal fluid, Anti-Infective Agents pharmacology, Disease Models, Animal, Drug Therapy, Combination, Meningitis, Pneumococcal metabolism, Naphthyridines cerebrospinal fluid, Naphthyridines pharmacology, Penicillin Resistance, Rabbits, Streptococcus pneumoniae drug effects, Time Factors, Vancomycin cerebrospinal fluid, Vancomycin pharmacology, Anti-Infective Agents therapeutic use, Fluoroquinolones, Meningitis, Pneumococcal drug therapy, Naphthyridines therapeutic use, Vancomycin therapeutic use
Abstract

Trovafloxacin, a new fluoroquinolone, produced bactericidal activity (-0.33 +/- 0.13 delta log10 CFU/ml.h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 delta log10 CFU/ml.h; i.v. admininistered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 micrograms/ml). The combination of both drugs significantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 delta log10 CFU/ml.h) compared to that produced by either monotherapy. These results were also confirmed in vitro.

Published
1999
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