1. Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products
- Author
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Brouwer, Michael S.M., Tehrani, Kamaleddin H.M.E., Rapallini, Michel, Geurts, Yvon, Kant, Arie, Harders, Frank, Mashayekhi, Vida, Martin, Nathaniel I., Bossers, Alex, Mevius, Dik J., Wit, Ben, Veldman, Kees T., Celbiologie, Sub Cell Biology, Klinische infectiologie en microb. lab., dI&I I&I-4, Celbiologie, Sub Cell Biology, Klinische infectiologie en microb. lab., and dI&I I&I-4
- Subjects
Epidemiology ,Cephalosporin ,Antimicrobial resistance ,Plasmid ,carbapenemase ,Pharmacology (medical) ,chemistry.chemical_classification ,0303 health sciences ,education.field_of_study ,biology ,Bacteriologie ,Enterobacter ,Bacteriology, Host Pathogen Interaction & Diagnostics ,Anti-Bacterial Agents ,Infectious Diseases ,Plasmids ,medicine.drug_class ,Enterobacter cloacae complex ,Bioinformatica & Diermodellen ,Population ,Microbial Sensitivity Tests ,beta-Lactamases ,Microbiology ,Carbapenemase ,03 medical and health sciences ,Micro 3: Knowledge and Expertise ,Antibiotic resistance ,Bacterial Proteins ,Mechanisms of Resistance ,plasmid ,Bio-informatics & Animal models ,Enterobacter cloacae ,medicine ,Epidemiology, Bio-informatics & Animal models ,antimicrobial resistance ,education ,030304 developmental biology ,Host Pathogen Interaction & Diagnostics ,Epidemiologie ,Pharmacology ,030306 microbiology ,Bacteriology ,biology.organism_classification ,Host Pathogen Interactie & Diagnostiek ,Cephalosporins ,Enzyme ,chemistry ,Epidemiologie, Bioinformatica & Diermodellen ,Bacteriologie, Host Pathogen Interactie & Diagnostiek ,Micro 3: Kennis en Expertise ,Bacteria - Abstract
Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids., Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A β-lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.
- Published
- 2018