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Your search keyword '"Matté MH"' showing total 2 results
Start Over Author "Matté MH" Journal antimicrobial agents and chemotherapy
2 results on '"Matté MH"'

1. First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil.

Author

Fernandes MR, McCulloch JA, Vianello MA, Moura Q, Pérez-Chaparro PJ, Esposito F, Sartori L, Dropa M, Matté MH, Lira DP, Mamizuka EM, and Lincopan N

Subjects
Aged, Brazil, Drug Resistance, Bacterial drug effects, Escherichia coli genetics, Escherichia coli Infections drug therapy, Escherichia coli Infections microbiology, Humans, Male, Microbial Sensitivity Tests, Plasmids drug effects, Plasmids genetics, Colistin pharmacology, Drug Resistance, Bacterial genetics, Escherichia coli drug effects, Escherichia coli isolation & purification, Escherichia coli Proteins genetics
Abstract

A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 plasmids that were recently identified in Enterobacteriaceae from food, animal, and human samples recovered on different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene., (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

Published
2016
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2. Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil.

Author

Dropa M, Ghiglione B, Matté MH, Balsalobre LC, Lincopan N, Matté GR, Gutkind G, and Power P

Subjects
Anti-Bacterial Agents pharmacology, Brazil, Ceftazidime pharmacology, Integrins genetics, Kinetics, Plasmids genetics, beta-Lactamases metabolism, Providencia genetics, beta-Lactamases genetics
Abstract

CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Published
2015
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