1. Control of Staphylococcal Adhesion to Polymethylmethacrylate and Enhancement of Susceptibility to Antibiotics by Poloxamer 407
- Author
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Bernard Rouveix, Marie-Laure Joly-Guillou, François Faurisson, and Marie-Laure Veyries
- Subjects
Staphylococcus aureus ,Micrococcaceae ,medicine.drug_class ,Staphylococcus ,Antibiotics ,Microbial Sensitivity Tests ,Poloxamer ,medicine.disease_cause ,Bacterial Adhesion ,Microbiology ,Vancomycin ,Staphylococcus epidermidis ,medicine ,Polymethyl Methacrylate ,Experimental Therapeutics ,Pharmacology (medical) ,Antibacterial agent ,Pharmacology ,biology ,Chemistry ,Drug Synergism ,biology.organism_classification ,Anti-Bacterial Agents ,Infectious Diseases ,Poloxamer 407 ,medicine.drug - Abstract
We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%) whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to antibiotic activity, suggesting that combination of P407 with antibiotics could be a promising approach to the prevention of infection of foreign material.
- Published
- 2000
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