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Start Over Author "Jinzhao Long" Journal antimicrobial agents and chemotherapy
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1. Genomic Insights into CRISPR-Harboring Plasmids in the Klebsiella Genus: Distribution, Backbone Structures, Antibiotic Resistance, and Virulence Determinant Profiles

Author

Jinzhao Long, Jiangfeng Zhang, Yanyan Xi, Jiaxue Zhao, Yuefei Jin, Haiyan Yang, Shuaiyin Chen, and Guangcai Duan

Subjects
Pharmacology, Infectious Diseases, Pharmacology (medical)
Abstract

CRISPR systems are often encoded by many prokaryotes as adaptive defense against mobile genetic elements (MGEs), but several MGEs also recruit CRISPR components to perform additional biological functions. Type IV-A systems are identified in Klebsiella plasmids, yet the distribution, characterization, and role of these plasmids carrying CRISPR systems in the whole Klebsiella genus remain unclear. Here, we performed large-scale comparative analysis of these plasmids using publicly available plasmid genomes.

Published
2023

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