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4 results on '"Hao, Yuxin"'

3. Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumanniiIsolate

Author

Wang, Liyuan, Liu, Dejun, Lv, Yuan, Cui, Lanqing, Li, Yun, Li, Tianmeng, Song, Huangwei, Hao, Yuxin, Shen, Jianzhong, Wang, Yang, and Walsh, Timothy R.

Abstract

A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumanniiisolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumanniivia electrotransformation.

Published
2019
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4. Emerging erm(B)-Mediated Macrolide Resistance Associated with Novel Multidrug Resistance Genomic Islands in Campylobacter

Author

Liu, Dejun, Liu, Weiwen, Lv, Ziquan, Xia, Junjie, Li, Xing, Hao, Yuxin, Zhou, Ying, Yao, Hong, Liu, Zhihai, Wang, Yang, Shen, Jianzhong, Ke, Yuebin, and Shen, Zhangqi

Abstract

The rapid dissemination of the macrolide resistance gene erm(B) will likely compromise the efficacy of macrolides as the treatment of choice for campylobacteriosis. More importantly, erm(B) is always associated with several multidrug resistance genomic islands (MDRGIs), which confer resistance to multiple other antimicrobials.

Published
2019
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