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2. KPC-Like Carbapenemase-Producing EnterobacteriaceaeColonizing Patients in Europe and Israel

Author

Baraniak, A., Izdebski, R., Fiett, J., Herda, M., Derde, L. P. G., Bonten, M. J. M., Adler, A., Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-Buisson, C., and Gniadkowski, M.

Abstract

ABSTRACTIn a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniaecarbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniaesequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPCplatforms were observed, among which IncFIIK-FIBKplasmids with blaKPC-2/-3genes in the Tn4401a transposon prevailed.

Published
2016
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3. KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel.

Author

Baraniak A, Izdebski R, Fiett J, Herda M, Derde LP, Bonten MJ, Adler A, Carmeli Y, Goossens H, Hryniewicz W, Brun-Buisson C, and Gniadkowski M

Subjects
Citrobacter freundii drug effects, Citrobacter freundii genetics, Citrobacter freundii isolation & purification, DNA Transposable Elements genetics, Enterobacteriaceae Infections microbiology, Escherichia coli drug effects, Escherichia coli genetics, Escherichia coli isolation & purification, Europe, Humans, Israel, Klebsiella pneumoniae genetics, Klebsiella pneumoniae isolation & purification, Plasmids genetics, Anti-Bacterial Agents therapeutic use, Bacterial Proteins biosynthesis, Bacterial Proteins genetics, Carbapenems therapeutic use, Enterobacteriaceae Infections drug therapy, Klebsiella pneumoniae drug effects, beta-Lactamases biosynthesis, beta-Lactamases genetics
Abstract

In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed., (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

Published
2015
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