1. Epidemiology of Carbapenem-Resistant Enterobacteriaceae Infections: Report from the China CRE Network.
- Author
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Zhang Y, Wang Q, Yin Y, Chen H, Jin L, Gu B, Xie L, Yang C, Ma X, Li H, Li W, Zhang X, Liao K, Man S, Wang S, Wen H, Li B, Guo Z, Tian J, Pei F, Liu L, Zhang L, Zou C, Hu T, Cai J, Yang H, Huang J, Jia X, Huang W, Cao B, and Wang H
- Subjects
- Aged, Anti-Bacterial Agents pharmacology, Bacteremia drug therapy, Bacteremia microbiology, Bacterial Proteins metabolism, Carbapenem-Resistant Enterobacteriaceae metabolism, China, Citrobacter freundii drug effects, Citrobacter freundii metabolism, Enterobacter cloacae drug effects, Enterobacter cloacae metabolism, Enterobacteriaceae Infections microbiology, Escherichia coli drug effects, Escherichia coli metabolism, Female, Humans, Klebsiella Infections drug therapy, Klebsiella Infections microbiology, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae metabolism, Male, Microbial Sensitivity Tests methods, Middle Aged, Polymyxin B pharmacology, Urinary Tract Infections drug therapy, Urinary Tract Infections microbiology, beta-Lactamases metabolism, Carbapenem-Resistant Enterobacteriaceae drug effects, Carbapenems pharmacology, Enterobacteriaceae Infections drug therapy
- Abstract
Carbapenem-resistant Enterobacteriaceae (CRE) infection is highly endemic in China, but estimates of the infection burden are lacking. We established the incidence of CRE infection from a multicenter study that covered 25 tertiary hospitals in 14 provinces. CRE cases defined as carbapenem-nonsusceptible Citrobacter freundii , Escherichia coli , Enterobacter cloacae , or Klebsiella pneumoniae infections during January to December 2015 were collected and reviewed from medical records. Antimicrobial susceptibility testing and carbapenemase gene identification were performed. Among 664 CRE cases, most were caused by K. pneumoniae (73.9%), followed by E. coli (16.6%) and E. cloacae (7.1%). The overall CRE infection incidence per 10,000 discharges was 4.0 and differed significantly by region, with the highest in Jiangsu (14.97) and the lowest in Qinghai (0.34). Underlying comorbidities were found in 83.8% of patients; the median patient age was 62 years (range, 45 to 74 years), and 450 (67.8%) patients were male. Lower respiratory tract infections (65.4%) were the most common, followed by urinary tract infection (16.6%), intra-abdominal infection (7.7%), and bacteremia (7.7%). The overall hospital mortality rate was 33.5%. All isolates showed nonsusceptibility to carbapenems and cephalosporins. The susceptibility rate of polymyxin B was >90%. Tigecycline demonstrated a higher susceptibility rate against E. coli than against K. pneumoniae (90.9% versus 40.2%). Of 155 clinical isolates analyzed, 89% produced carbapenemases, with a majority of isolates producing KPC (50%) or NDM (33.5%)-type beta-lactamases among K. pneumoniae and E. coli The incidence of CRE infection in China was 4.0 per 10,000 discharges. The patient-based disease burden in tertiary hospitals in China is severe, suggesting an urgent need to enhance infection control., (Copyright © 2018 American Society for Microbiology.)
- Published
- 2018
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