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Start Over Author "Akira Gotoh" Journal antimicrobial agents and chemotherapy
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1. In vitro activities of rabeprazole, a novel proton pump inhibitor, and its thioether derivative alone and in combination with other antimicrobials against recent clinical isolates of Helicobacter pylori

Author

Masaru Yamaguchi, Kozue Oana, Yuko Takahashi, Yoshiyuki Kawakami, Yukie Okimura, Tsutomu Katsuyama, Akira Gotoh, Tadashi Okabe, and Takayuki Akahane

Subjects
medicine.drug_class, Rabeprazole, Lansoprazole, Proton-pump inhibitor, Microbial Sensitivity Tests, Pharmacology, 2-Pyridinylmethylsulfinylbenzimidazoles, Clarithromycin, medicine, Humans, Pharmacology (medical), Drug Interactions, Rabeprazole Sodium, Omeprazole, Antibacterial agent, biology, Helicobacter pylori, Chemistry, Proton Pump Inhibitors, biology.organism_classification, Anti-Ulcer Agents, Anti-Bacterial Agents, Infectious Diseases, Susceptibility, Benzimidazoles, medicine.drug
Abstract

The MICs of rabeprazole sodium (RPZ), a newly developed benzimidazole proton pump inhibitor (PPI), against 133 clinical Helicobacter pylori strains revealed a higher degree of activity than the another two PPIs, lansoprazole and omeprazole. Time-kill curve assays of RPZ, when combined with amoxicillin, clarithromycin, or metronidazole, disclosed that synergistic effects were demonstrated in combination with each antibiotic examined. Moreover, no apparent antagonistic effect appeared among all of the strains tested.

Published
2000

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