1. Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats
- Author
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E D Funderburg, R. F. Schinazi, S. G. Smith, and F. D. Boudinot
- Subjects
Male ,Pharmacology ,Chromatography ,Chemistry ,Radiochemistry ,Half-life ,Rats, Inbred Strains ,Antiviral Agents ,3'-fluoro-3'-deoxythymidine ,High-performance liquid chromatography ,Dideoxynucleosides ,Rats ,Stavudine ,Infectious Diseases ,Pharmacokinetics ,parasitic diseases ,Animals ,Pharmacology (medical) ,Chromatography, High Pressure Liquid ,Half-Life ,Research Article - Abstract
Concentrations of 3'-fluoro-3'-deoxythymidine (FDT) and 3'-deoxy-2',3'-didehydrothymidine (D4T) in plasma declined in a biexponential fashion. Total clearance of D4T (1.75 +/- 0.22 liters/h/kg; mean +/- standard deviation) was significantly greater than that of FDT (1.19 +/- 0.19 liters/h/kg) owing to greater renal and nonrenal clearances of the former. Steady-state volumes of distribution of FDT (1.20 +/- 0.12 liters/kg) and D4T (1.07 +/- 0.15 liters/kg) were similar.
- Published
- 1991
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