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Start Over Descriptor "tumour oxygenation" Journal anticancer research
4 results on '"tumour oxygenation"'

1. Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy

Author

Emely Lindblom, Iuliana Toma-Dasu, and Alexandru Dasu

Subjects
Cancer Research, medicine.medical_specialty, Cell Survival, medicine.medical_treatment, Radiosurgery, Models, Biological, Radiation Tolerance, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Vascular collapse, medicine, High doses, Humans, Computer Simulation, Hypoxia, business.industry, General Medicine, Hypoxia (medical), Tumour oxygenation, Oxygen, Radiation therapy, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Blood Vessels, Dose Fractionation, Radiation, Radiology, medicine.symptom, business, Stereotactic body radiotherapy
Abstract

This study investigated the impact of temporary vascular collapse on tumour control probability (TCP) in stereotactic body radiotherapy (SBRT), taking into account different radiosensitivities of chronically and acutely hypoxic cells.Three-dimensional tumours with heterogeneous oxygenation were simulated assuming different fractions of collapsed vessels at every treatment fraction. The modelled tumours contained a chronically hypoxic subvolume of 30-60% of the tumour diameter, and a hypoxic fraction ≤5 mm Hg of 30-50%. The rest of the tumours were well-oxygenated at the start of the simulated treatment.For all simulated cases, the largest reduction in TCP from 97% to 2% was found in a tumour with a small chronically hypoxic core treated with 60 Gy in eight fractions and assuming a treatment-induced vascular collapse of 35% in the well-oxygenated region.The timing of SBRT fractions should be considered together with the tumour oxygenation to avoid loss of TCP in SBRT.

Published
2019
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2. Radiation-induced Vascular Damage and the Impact on the Treatment Outcome of Stereotactic Body Radiotherapy

Author

Maciej Kujawski, Jamison Brooks, Alexandru Dasu, Iuliana Toma-Dasu, Emely Lindblom, and Susanta K. Hui

Subjects
Cancer Research, medicine.medical_specialty, Treatment outcome, Radiation induced, Breast Neoplasms, Radiosurgery, Models, Biological, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, business.industry, General Medicine, Hypoxia (medical), Tumour oxygenation, Cell Hypoxia, Microscopy, Fluorescence, Multiphoton, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Blood Vessels, Female, Radiology, Dose Fractionation, Radiation, medicine.symptom, business, Stereotactic body radiotherapy, Neoplasm Transplantation
Abstract

BACKGROUND/AIM: The aim of this study was to investigate radiation-induced tumour vascular damage and its impact thereof on the outcome of stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: Vessel densities in animal tumours before and after a single dose of 20 Gy were quantified and used as input for simulations of three-dimensional tumours with heterogeneous oxygenation. SBRT treatments of the modelled tumours in 1–8 fractions were simulated. The impact of vessel collapse on the outcome of SBRT was investigated by calculating tumour control probability (TCP) and the dose required to obtain a TCP of 50% (D(50)). RESULTS: A radiation-induced increase of acute hypoxia in tumours during SBRT treatment could be simulated based on the experimental data. The D(50) values for these tumours were higher than for the simulated tumours without vessel collapse. CONCLUSION: The vascular changes after high doses of radiation could compromise the outcome of SBRT by increasing tumour hypoxia.

Published
2019

3. Radiation-induced Vascular Damage and the Impact on the Treatment Outcome of Stereotactic Body Radiotherapy.

Author

Lindblom EK, Hui S, Brooks J, Dasu A, Kujawski M, and Toma-Dasu I

Subjects
Animals, Blood Vessels diagnostic imaging, Breast Neoplasms blood supply, Breast Neoplasms diagnostic imaging, Cell Hypoxia, Cell Line, Tumor, Dose Fractionation, Radiation, Female, Humans, Mice, Microscopy, Fluorescence, Multiphoton, Models, Biological, Neoplasm Transplantation, Treatment Outcome, Blood Vessels injuries, Blood Vessels radiation effects, Breast Neoplasms radiotherapy, Radiosurgery adverse effects
Abstract

Background/aim: The aim of this study was to investigate radiation-induced tumour vascular damage and its impact thereof on the outcome of stereotactic body radiotherapy (SBRT)., Materials and Methods: Vessel densities in animal tumours before and after a single dose of 20 Gy were quantified and used as input for simulations of three-dimensional tumours with heterogeneous oxygenation. SBRT treatments of the modelled tumours in 1-8 fractions were simulated. The impact of vessel collapse on the outcome of SBRT was investigated by calculating tumour control probability (TCP) and the dose required to obtain a TCP of 50% (D 50 )., Results: A radiation-induced increase of acute hypoxia in tumours during SBRT treatment could be simulated based on the experimental data. The D 50 values for these tumours were higher than for the simulated tumours without vessel collapse., Conclusion: The vascular changes after high doses of radiation could compromise the outcome of SBRT by increasing tumour hypoxia., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2019
Full Text
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4. Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy.

Author

Lindblom EK, Dasu A, and Toma-Dasu I

Subjects
Blood Vessels injuries, Blood Vessels physiopathology, Carcinoma, Non-Small-Cell Lung complications, Carcinoma, Non-Small-Cell Lung pathology, Cell Survival, Computer Simulation, Dose Fractionation, Radiation, Humans, Hypoxia complications, Hypoxia etiology, Models, Biological, Oxygen metabolism, Radiation Tolerance, Treatment Outcome, Blood Vessels radiation effects, Carcinoma, Non-Small-Cell Lung radiotherapy, Hypoxia physiopathology, Radiosurgery adverse effects
Abstract

Background/aim: This study investigated the impact of temporary vascular collapse on tumour control probability (TCP) in stereotactic body radiotherapy (SBRT), taking into account different radiosensitivities of chronically and acutely hypoxic cells., Materials and Methods: Three-dimensional tumours with heterogeneous oxygenation were simulated assuming different fractions of collapsed vessels at every treatment fraction. The modelled tumours contained a chronically hypoxic subvolume of 30-60% of the tumour diameter, and a hypoxic fraction ≤5 mm Hg of 30-50%. The rest of the tumours were well-oxygenated at the start of the simulated treatment., Results: For all simulated cases, the largest reduction in TCP from 97% to 2% was found in a tumour with a small chronically hypoxic core treated with 60 Gy in eight fractions and assuming a treatment-induced vascular collapse of 35% in the well-oxygenated region., Conclusion: The timing of SBRT fractions should be considered together with the tumour oxygenation to avoid loss of TCP in SBRT., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2019
Full Text
View/download PDF

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