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Start Over Author "Wollschlaeger, Daniel" Journal anticancer research
2 results on '"Wollschlaeger, Daniel"'

2. Influence of Local Recurrence and Distant Metastasis on Prognosis After Local Excision of Rectal Carcinoma.

Author

Junginger T, Goenner U, Hitzler M, Trinh TT, Lollert A, Heintz A, Wollschlaeger D, and Blettner M

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma mortality, Carcinoma secondary, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm, Residual, Proportional Hazards Models, Rectal Neoplasms mortality, Rectal Neoplasms pathology, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Carcinoma surgery, Neoplasm Recurrence, Local, Rectal Neoplasms surgery, Transanal Endoscopic Microsurgery adverse effects, Transanal Endoscopic Microsurgery mortality
Abstract

Background: Influence of local recurrence (LR) on prognosis after a local excision (LE) for rectal cancer is unclear., Patients and Methods: A total of 152 patients were retrospectively assigned to one of three groups: Groups 1 and 2: complete and incomplete resection respectively, for low-risk carcinoma; group 3: high-risk carcinoma. We evaluated LR, distant metastasis (DM), overall survival, and cancer-specific survival (CSS)., Results: LR rates were 10.4%, 43% and 29% for groups 1-3, respectively (p=0.002). In all three groups, DM incidence was low in patients without LR, but high in patients with LR (p<0.0001). Prior LR was an important risk factor for DM (hazard ratio: 14.1, 95% confidence interval=4.3-45.8, p<0.0001). DM significantly reduced CSS., Conclusion: There is a strong association between LR and DM independently in the cause of LR. Avoiding LE for high-risk carcinoma and complete LE of low-risk carcinoma are essential to reduce LR and DM., (Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2016

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