1. Carboplatin plus weekly paclitaxel treatment in non-small cell lung cancer patients with interstitial lung disease.
- Author
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Shukuya T, Ishiwata T, Hara M, Muraki K, Shibayama R, Koyama R, and Takahashi K
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Carboplatin administration & dosage, Carboplatin adverse effects, Carcinoma, Non-Small-Cell Lung pathology, Cohort Studies, Disease-Free Survival, Drug Administration Schedule, Female, Humans, Lung Diseases, Interstitial pathology, Male, Middle Aged, Paclitaxel administration & dosage, Paclitaxel adverse effects, Patient Compliance, Retrospective Studies, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Diseases, Interstitial drug therapy, Lung Neoplasms drug therapy
- Abstract
Background: Since advanced non-small cell lung cancer (NSCLC) patients with the interstitial lung disease (ILD) have been excluded from clinical trials, it is uncertain whether chemotherapy really provides a benefit to these patients., Patients and Methods: Fifteen advanced NSCLC patients with ILD that was detected on the chest X-rays were enrolled in this study. Carboplatin plus paclitaxel was administered by two methods (method A or method B). Method A: Carboplatin (AUC 6, day 1) and paclitaxel (70 mg/m(2), days 1, 8, 15) were administered every four weeks. Method B: Carboplatin (AUC 2, day 1, 8, 15) and paclitaxel (60 mg/m(2), days 1, 8, 15) were administered every four weeks., Results: The response rate and the disease control rate were 33% and 53%. The median progression-free survival and the median overall survival time were 2.5 months and 7.0 months, respectively. The hematological toxicities were tolerable, but a grade 3 or higher pneumonitis was observed in 4 patients (27%)., Conclusion: Carboplatin plus weekly paclitaxel must be administered carefully to advanced NSCLC patients with ILD that is detected on chest X-rays after a sufficient evaluation of the risks and the benefits.
- Published
- 2010