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Start Over Author "Peter Trillenberg" Journal anticancer research
2 results on '"Peter Trillenberg"'

2. A New Survival Score for Patients Receiving Radiotherapy for Newly Diagnosed Glioblastoma Multiforme

Author

Jan Leppert, Dirk Rades, Jaspar Witteler, Matteo M Bonsanto, Steven E. Schild, and Peter Trillenberg

Subjects
Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Newly diagnosed, Kaplan-Meier Estimate, Resection, Young Adult, Internal medicine, Promoter methylation, medicine, Humans, Aged, Aged, 80 and over, Performance status, Radiotherapy, business.industry, Disease Management, General Medicine, Middle Aged, medicine.disease, Prognosis, Combined Modality Therapy, Radiation therapy, Treatment Outcome, Female, business, Glioblastoma
Abstract

BACKGROUND/AIM In a previous study investigating radiotherapy for newly diagnosed glioblastoma multiforme (GBM), significant or almost significant associations with survival were found for performance status, upfront resection, O6-methylguanine-DNA methyl-transferase (MGMT) promoter methylation and unifocal GBM. This study aimed to create a survival score based on these factors. PATIENTS AND METHODS Most of the 81 patients included received resection of GBM followed by radiochemotherapy (59.4 Gy/33 or 60 Gy/30 fractions). The previously identified predictors of survival were re-evaluated. Factors significantly associated with survival were used for the score. RESULTS All factors were significantly associated with survival. For each factor, 0 points (less favorable survival) or 1 point (more favorable survival) were assigned and added for each patient. Three groups were designed, 0-1 (n=10), 2 (n=21) and 3-4 points (n=50); 12-month survival rates were 0%, 38% and 78% (p

Published
2020

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