1. Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma.
- Author
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Talaat IM, Abu-Gharbieh E, Hussein A, Hachim M, Sobhy I, Eladl M, and El-Huneidi W
- Subjects
- Aged, Amino Acid Sequence genetics, Biomarkers, Tumor genetics, Carcinoma, Renal Cell pathology, Carrier Proteins genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Prognosis, Progression-Free Survival, Calcium-Binding Proteins genetics, Carcinoma, Renal Cell genetics, Ki-67 Antigen genetics, Receptor, EphA2 genetics
- Abstract
Background/aim: Renal cell carcinoma (RCC) is among the most common renal malignancies and requires reliable biomarkers for optimum diagnosis and prognosis. Copines are a family of calcium-dependent phospholipid-binding proteins that were reported to be associated with various cancers. We aimed to investigate the prognostic value of Copines 1 and 3 in RCC patients., Materials and Methods: Copines 1 and 3 bioinformatics analysis and immunohistochemical (IHC) staining were performed on patients with RCC., Results: The findings revealed significant association between Copine 1 expression and the patients' age, nuclear grade, and tumor stage. Bioinformatics analysis showed a similar trend for the mRNA expression of CPNE1, the gene that encodes Copine 1. Interestingly, results revealed a positive association between Copine 1 and both EphA and Ki-67 expression levels. Noteworthy, there was no significant association between Copine 3 expression and any parameters., Conclusion: Copine 1 may be used as an independent biomarker or in combination with both EphA2 and Ki-67 to predict disease outcome., (Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2022
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