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Start Over Author "CARINI F" Journal anticancer research
4 results on '"CARINI F"'

1. Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel

Author

Rappa F, Sciume C, Lo Bello M, Cc, Bavisotto, Marino Gammazza A, Barone R, Campanella C, David S, Carini F, Zarcone F, Rizzuto S, Lena A, Tomasello G, Ml, Uzzo, Gf, Spatola, Bonaventura G, Leone A, Gerbino A, Cappello F, Fabio BUCCHIERI, Zummo G, Farina F, Rappa, F, Sciumè, C, Lo Bello, M, Caruso Bavisotto, C, Marino Gammazza, A, Barone, R, Campanella, C, David, S, Carini, F, Zarcone, F, Rizzuto, S, Lena, A, Tomasello, G, Uzzo, ML, Spatola, GF, Bonaventura, G, Leone, A, Gerbino, A, Cappello, F, Bucchieri, F, Zummo, G, and Farina, F

Subjects
Hsp10, Reverse Transcriptase Polymerase Chain Reaction, large bowel adenocarcinoma, Blotting, Western, Colonic Neoplasms, RT-PCR, Chaperonin 10, Humans, Hsp90, HSP90 Heat-Shock Proteins, Adenocarcinoma, Intestinal Mucosa, Immunohistochemistry
Abstract

Heat shock proteins (Hsps) assist other proteins in their folding and drive the degradation of defective proteins. During evolution, these proteins have also acquired other roles. Hsp10 is involved in immunomodulation and tumor progression. Hsp90 stabilizes a range of "client" proteins involved in cell signaling. The present study evaluated the expression levels of Hsp10 and Hsp90 in normal mucosa and adenocarcinoma samples of human large bowel.Samples of normal mucosa and adenocarcinoma were collected and Reverse transcriptase-polymerase chain reaction RT-PCR, western blotting (WB) analyses, as well as immunohistochemistry were performed to evaluate the expression levels of Hsp10 and Hsp90.RT-PCR showed a higher gene expression of Hsp10 and Hsp90 in adenocarcinoma samples compared to healthy mucosa. WB results confirmed these findings. Immunohistochemistry revealed higher levels of Hsp10 in adenocarcinoma in both the epithelium and the lamina propria, while Hsp90 expression was higher in the adenocarcinoma samples only in the lamina propria.Hsp10 and Hsp90 may be involved in large bowel carcinogenesis.

Published
2014

2. Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

Author

Provvidenza Damiani, Rosalyn A. Jurjus, Alice Gerges Geagea, Francesca Rappa, Giovanni Tomasello, Margherita Mazzola, Abdo Jurjus, Sahar Al Kattar, Francesco Carini, Angelo Leone, Tarek Bou-Assi, Carini,F, Mazzola,M, Rappa,F, Jurjus,A, Gerges Geagea,A, Al Kattar,S, Bou-Assi,T, Jurjus,R, Damiani,P, Leone,A, and Tomasello,G

Subjects
0301 basic medicine, Cancer Research, Carcinogenesis, Settore MED/06 - Oncologia Medica, Colorectal cancer, DNA repair, Cell, Review, Colorectal Neoplasm, medicine.disease_cause, Antioxidants, 03 medical and health sciences, 0302 clinical medicine, Dysbiosis, Oxidative stress, Animals, Colorectal Neoplasms, Humans, Reactive Oxygen Species, Oxidative Stress, Oncology, Medicine, colorectal cancer, dysbiosis, microbioma, oxodative stress, carcinogenesi, Carcinogenesi, chemistry.chemical_classification, Reactive oxygen species, Animal, business.industry, Oxidative Stre, General Medicine, Colorectal carcinogenesis, medicine.disease, Dysbiosi, Settore MED/18 - Chirurgia Generale, colorectal cancer, dysbiosis, microbioma, oxodative stress, carcinogenesis, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Cancer research, Antioxidant, Reactive Oxygen Specie, business, Human
Abstract

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.

Published
2017

3. Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants.

Author

Carini F, Mazzola M, Rappa F, Jurjus A, Geagea AG, Al Kattar S, Bou-Assi T, Jurjus R, Damiani P, Leone A, and Tomasello G

Subjects
Animals, Carcinogenesis drug effects, Humans, Antioxidants pharmacology, Carcinogenesis pathology, Colorectal Neoplasms pathology, Oxidative Stress drug effects, Reactive Oxygen Species metabolism
Abstract

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2017
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4. HSP-molecular chaperones in cancer biogenesis and tumor therapy: an overview.

Author

Rappa F, Farina F, Zummo G, David S, Campanella C, Carini F, Tomasello G, Damiani P, Cappello F, DE Macario EC, and Macario AJ

Subjects
Animals, Cancer Vaccines immunology, Cancer Vaccines pharmacology, Heat-Shock Proteins antagonists & inhibitors, Heat-Shock Proteins immunology, Humans, Molecular Targeted Therapy, Neoplasms pathology, Cell Transformation, Neoplastic metabolism, Heat-Shock Proteins metabolism, Neoplasms metabolism, Neoplasms therapy
Abstract

Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by 'mistake'. In the latter case, the chaperone is structurally and functionally normal but participates in pathways that favor disease, although in some cases the chaperone may have post-translational modifications that may lead it to change its location and function and, thus, to become pathogenic. For example, HSP-chaperones are involved in carcinogenesis in various ways, so that some forms of cancer may be considered 'chaperonopathies by mistake'. This concept suggests new strategies for anticancer therapy (chaperonotherapy), in which the primary targets or therapeutic agents are chaperones. Chaperonotherapy consists of the utilization of HSP-chaperones for treating chaperonopathies, including cancer. Negative chaperonotherapy is aimed at eliminating or blocking the action of chaperones that favor carcinogenesis or other diseases, whereas positive chaperonotherapy uses chaperones, genes or proteins, to fight against diseases, such as cancer, by stimulating the immune system or the cellular defenses against stress.

Published
2012

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