Search

Your search keyword '"C. Bezu"' showing total 3 results
Start Over Author "C. Bezu" Journal anticancer research
3 results on '"C. Bezu"'

1. Predictive factors for breast cancer in patients diagnosed with ductal intraepithelial neoplasia, grade 1B

Author

S, Bendifallah, N, Chabbert-Buffet, N, Maurin, J, Chopier, M, Antoine, C, Bezu, S, Uzan, and R, Rouzier

Subjects
Carcinoma, Intraductal, Noninfiltrating, Logistic Models, Risk Factors, Carcinoma, Ductal, Breast, Humans, Breast Neoplasms, Female, Middle Aged, Neoplasm Grading, Prognosis, Carcinoma in Situ
Abstract

For ductal intraepithelial neoplasia, grade 1B, studies that predict breast cancer risk after an 11-gauge vacuum-assisted breast biopsy have yielded contradictory results. In order to identify a predictive model of breast cancer risk, we assessed the underestimation rate according to radiological and clinical findings.Our study involved 212 patients. We compared the area under the receiver operating characteristic curves and the clinical utility of a logistic regression and partitioning model.Overall upgrade to malignancy occurred in 42 (19.8%) out of the 212 cases. The area under the curve for the logistic regression and partitioning model were 0.65 (95% confidence interval=0.61-0.70) and 0.58 (95% confidence interval=0.54-0.62), respectively. The lowest predicted underestimation rate obtained with the logistic regression model was 9.5%.From this large series, we were unable to define any accurate safety model for breast cancer. Surgery should be thus recommended.

Published
2012

2. Impact of immunohistochemical analysis of sentinel lymph node biopsy on breast cancer management.

Author

Chéreau E, Bezu C, Gligorov J, Sakr R, Antoine M, Daraï E, Uzan S, and Rouzier R

Subjects
Adult, Aged, Aged, 80 and over, Breast Neoplasms metabolism, Female, Humans, Immunohistochemistry, Middle Aged, Breast Neoplasms pathology, Breast Neoplasms therapy, Sentinel Lymph Node Biopsy
Abstract

Background: Little evidence of the impact of immunohistochemical analysis (IHC) on the indications for adjuvant therapies is available. This study determined the modification rate of adjuvant chemotherapy and lymph node area radiotherapy using IHC and its impact on survival., Patients and Methods: Between 2001 and 2005, 416 patients underwent surgery for invasive breast cancer with sentinel lymph node (SLN) biopsy., Results: A total of 112 patients had positive SLNs: 12.5% isolated tumor cells, 35.7% micrometastasis and 51.8% macrometastasis. Only 4% of patients (14 out of 342 patients) had modified indications for chemotherapy and 7% of patients (25 out of 342) for lymph node area radiotherapy due to IHC findings., Conclusion: IHC analysis led to modifications in adjuvant chemotherapy and lymph node area radiotherapy in 4% and 7% of patients, respectively. The prognosis of patients with nodal metastasis discovered by ultrastaging was similar to that for conventional Haematoxylin-Eosin-Safran (HES) staining. Our data support the use of SLN ultrastaging.

Published
2012

3. Predictive factors for breast cancer in patients diagnosed with ductal intraepithelial neoplasia, grade 1B.

Author

Bendifallah S, Chabbert-Buffet N, Maurin N, Chopier J, Antoine M, Bezu C, Uzan S, and Rouzier R

Subjects
Female, Humans, Logistic Models, Middle Aged, Neoplasm Grading, Prognosis, Risk Factors, Breast Neoplasms pathology, Carcinoma in Situ pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Intraductal, Noninfiltrating pathology
Abstract

Background: For ductal intraepithelial neoplasia, grade 1B, studies that predict breast cancer risk after an 11-gauge vacuum-assisted breast biopsy have yielded contradictory results. In order to identify a predictive model of breast cancer risk, we assessed the underestimation rate according to radiological and clinical findings., Patients and Methods: Our study involved 212 patients. We compared the area under the receiver operating characteristic curves and the clinical utility of a logistic regression and partitioning model., Results: Overall upgrade to malignancy occurred in 42 (19.8%) out of the 212 cases. The area under the curve for the logistic regression and partitioning model were 0.65 (95% confidence interval=0.61-0.70) and 0.58 (95% confidence interval=0.54-0.62), respectively. The lowest predicted underestimation rate obtained with the logistic regression model was 9.5%., Conclusion: From this large series, we were unable to define any accurate safety model for breast cancer. Surgery should be thus recommended.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results